Astros vs Cubs Prediction, Odds, Moneyline, Spread & Over/Under for June 27

Odds updated as of 6:11 a.m.

In MLB action on Friday, the Houston Astros take on the Chicago Cubs.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Astros vs Cubs Game Info

• Houston Astros (48-33) vs. Chicago Cubs (48-33)
• Date: Friday, June 27, 2025
• Time: 8:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and MARQ

Astros vs Cubs Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-112) | CHC: (-104)
• Spread: HOU: +1.5 (-182) | CHC: -1.5 (+150)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Astros vs Cubs Probable Starting Pitchers

Probable Pitchers: Brandon Walter (Astros) - 0-1, 3.80 ERA vs Cade Horton (Cubs) - 3-1, 3.73 ERA

The probable starters are Brandon Walter (0-1) for the Astros and Cade Horton (3-1) for the Cubs. Walter's team is 2-2-0 against the spread this season in his starts. Walter's team won his only start as a favorite this season. When Horton starts, the Cubs are 4-3-0 against the spread. The Cubs were the moneyline underdog for one Horton start this season -- they lost.

Astros vs Cubs Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (51.1%)

Astros vs Cubs Moneyline

• Houston is the favorite, -112 on the moneyline, while Chicago is a -104 underdog on the road.

Astros vs Cubs Spread

• The Cubs are 1.5-run favorites against the spread for this matchup with the Astros. The Cubs are +150 to cover, while the Astros are -182 to cover as a 1.5-run underdog on the runline.

Astros vs Cubs Over/Under

• Astros versus Cubs, on June 27, has an over/under of 8.5, with the over being -105 and the under -115.

Bet on Houston Astros vs. Chicago Cubs on FanDuel today!

Astros vs Cubs Betting Trends

• The Astros have been chosen as favorites in 55 games this year and have walked away with the win 33 times (60%) in those games.
• This season Houston has come away with a win 32 times in 54 chances when named as a favorite of at least -112 on the moneyline.
• The Astros and their opponents have gone over in 31 of their 80 games with a total set by sportsbooks this season.
• The Astros have posted a record of 41-39-0 against the spread this season.
• The Cubs have won nine of the 24 games they were the moneyline underdog this season (37.5%).
• When it has played as a moneyline underdog with odds of -104 or longer, Chicago has a record of 8-12 (40%).
• The Cubs have played in 79 games with a set over/under, and have combined with their opponents to go over the total 42 times (42-33-4).
• The Cubs have collected a 40-39-0 record against the spread this season.

Astros Player Leaders

• Jeremy Pena leads Houston in OBP (.379), slugging percentage (.492) and total hits (102) this season. He has a .324 batting average.
• Among all qualifying hitters in the majors, his batting average ranks fifth, his on-base percentage ranks 16th, and he is 26th in slugging.
• Pena will look for his fifth straight game with a hit in this matchup. In his last five games he is batting .263 with three doubles, a home run, a walk and two RBIs.
• Isaac Paredes is batting .251 with 10 doubles, a triple, 16 home runs and 42 walks, while slugging .463 with an on-base percentage of .357.
• Among qualified hitters, his batting average ranks him 95th, his on-base percentage 37th, and his slugging percentage 49th.
• Jose Altuve has 79 hits this season and has a slash line of .263/.321/.417.
• Jake Meyers has three home runs, 20 RBI and a batting average of .306 this season.
• Meyers heads into this matchup on a two-game hitting streak. During his last five outings he is hitting .294 with an RBI.

Cubs Player Leaders

• Kyle Tucker a has .395 on-base percentage to pace the Cubs. He's batting .287 while slugging .527.
• He is 27th in batting average, fifth in on-base percentage and 13th in slugging percentage among all qualified hitters in the majors.
• Pete Crow-Armstrong's 85 hits lead his team. He has a batting average of .272 while slugging .556 with an on-base percentage of .307.
• Including all qualified players, he ranks 51st in batting average, 118th in on-base percentage and sixth in slugging percentage.
• Seiya Suzuki is batting .256 with 19 doubles, two triples, 21 home runs and 28 walks.
• Nico Hoerner is slugging .368 to pace his team.

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