76ers vs. Cavaliers Prediction, Odds, Picks, Best Bets for Oct. 22

76ers vs. Cavaliers Game Info

• Date: Thursday, October 22, 2026
• Time: 7 p.m. ET
• Venue: Xfinity Mobile Arena -- Philadelphia, Pennsylvania
• Coverage: ESPN

The Philadelphia 76ers (1-0) take on the Cleveland Cavaliers (0-0) as just 2.5-point favorites on Thursday, October 22, 2026 at 7 p.m. ET on ESPN. The over/under is set at 236.5 in the matchup.

76ers vs. Cavaliers Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

76ers vs. Cavaliers Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Cavaliers win (51.9%)

76ers vs. Cavaliers Betting Trends

• The 76ers won 40 games against the spread last season, while failing to cover or pushing 42 times.
• The Cavaliers' ATS record as underdogs of 2.5 points or more was 6-4 last year.
• 76ers games hit the over 41 out of 82 times last season.
• The Cavaliers had 41 of their 82 games hit the over last season.
• Philadelphia did a better job covering the spread when playing on the road (22-18-1) than it did at home (18-22-1) last year.
• Last season, Cleveland was 17-23-1 at home against the spread (.415 winning percentage). On the road, it was 16-24-1 ATS (.390).

76ers Leaders

• Tyrese Maxey's numbers last season were 28.3 points, 4.1 boards and 6.6 assists per contest. He also drained 46.2% of his shots from the floor and 36.7% from 3-point range, with an average of 3.1 triples (ninth in NBA).
• Jaylen Brown's numbers last season were 28.7 points, 6.9 rebounds and 5.1 assists per contest. He drained 47.7% of his shots from the field and 34.7% from beyond the arc, with an average of 2 triples.
• LeBron James' numbers last season were 20.9 points, 6.1 rebounds and 7.2 assists per game. He made 51.5% of his shots from the floor and 31.7% from 3-point range, with an average of 1.3 triples.
• VJ Edgecombe recorded 16 points, 5.6 rebounds and 4.2 assists. He made 43.8% of his shots from the field and 35.4% from 3-point range, with 2 treys per contest.
• Last season, Joel Embiid averaged 26.9 points, 7.7 rebounds and 3.9 assists. He sank 48.9% of his shots from the floor and 33.3% from beyond the arc, with 1.4 triples per contest.

Cavaliers Leaders

• Donovan Mitchell collected 27.9 points, 4.5 boards and 5.7 assists last season. Defensively, he posted 1.5 steals (ninth in NBA) and 0.3 blocked shots.
• James Harden posted 23.6 points, 8 assists and 4.8 rebounds.
• Evan Mobley posted 18.2 points, 3.6 assists and 9 rebounds.
• Jarrett Allen posted 15.4 points, 8.5 rebounds and 1.8 assists. Defensively, he delivered 1 steal and 0.8 blocked shots.
• Jaylon Tyson recorded 13.2 points, 5.1 boards and 2.2 assists.

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