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NFL

2025 San Francisco 49ers Schedule, Results, TV Channel

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2025 San Francisco 49ers Schedule, Results, TV Channel

The San Francisco 49ers' schedule for the 2025 season is highlighted by a game Oct. 12 that finds them colliding with the Tampa Bay Buccaneers. We cover the 49ers' full NFL schedule in the article below. Looking for additional information on the San Francisco 49ers' 2025 results and NFL schedule? We've got you covered in the article below.

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49ers' 2025 Schedule

Date/Time
Opponent
Odds/Score
Location
TV Channel
Sunday, Sept. 7 at 4:05 p.m. ET@ Seahawks49ers (-2.5) | O/U: 45.5Lumen Field, Seattle, WashingtonFOX
Sunday, Sept. 14 at 1 p.m. ET@ Saints-Caesars Superdome, New Orleans, LouisianaFOX
Sunday, Sept. 21 at 4:25 p.m. ETCardinals-Levi's Stadium, Santa Clara, CaliforniaFOX
Sunday, Sept. 28 at 4:05 p.m. ETJaguars-Levi's Stadium, Santa Clara, CaliforniaFOX
Thursday, Oct. 2 at 8:15 p.m. ET@ Rams-SoFi Stadium, Inglewood, CaliforniaAmazon Prime Video
Sunday, Oct. 12 at 1 p.m. ET@ Buccaneers-Raymond James Stadium, Tampa, FloridaCBS
Sunday, Oct. 19 at 8:20 p.m. ETFalcons-Levi's Stadium, Santa Clara, CaliforniaNBC

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