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NFL

2025 San Francisco 49ers Schedule, Results, TV Channel

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2025 San Francisco 49ers Schedule, Results, TV Channel

The San Francisco 49ers' 2025 campaign kicks off on Sept. 7, when they go head to head against the Seattle Seahawks. Info on the 49ers' full NFL schedule can be seen below. For info on the San Francisco 49ers, including their 2025 results, NFL schedule, and where they sit in the NFC West, see the below article.

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49ers' 2025 Schedule

Date/Time
Opponent
Odds/Score
Location
TV Channel
Sunday, Sept. 7 at 4:05 p.m. ET@ Seahawks49ers (-1.5) | O/U: 45.5Lumen Field, Seattle, WashingtonFOX
Sunday, Sept. 14 at 1 p.m. ET@ Saints-Caesars Superdome, New Orleans, LouisianaFOX
Sunday, Sept. 21 at 4:25 p.m. ETCardinals-Levi's Stadium, Santa Clara, CaliforniaFOX
Sunday, Sept. 28 at 4:05 p.m. ETJaguars-Levi's Stadium, Santa Clara, CaliforniaFOX
Thursday, Oct. 2 at 8:15 p.m. ET@ Rams-SoFi Stadium, Inglewood, CaliforniaAmazon Prime Video
Sunday, Oct. 12 at 1 p.m. ET@ Buccaneers-Raymond James Stadium, Tampa, FloridaCBS
Sunday, Oct. 19 at 8:20 p.m. ETFalcons-Levi's Stadium, Santa Clara, CaliforniaNBC

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