Yankees vs Red Sox Prediction, Odds, Moneyline, Spread & Over/Under for April 21

Odds updated as of 2:12 a.m.

The MLB's Tuesday schedule includes the New York Yankees facing the Boston Red Sox.

We've got you covered, in terms of the vital information regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Yankees vs Red Sox Game Info

• New York Yankees (13-9) vs. Boston Red Sox (9-13)
• Date: Tuesday, April 21, 2026
• Time: 6:45 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: TBS, NESN+, and YES

Yankees vs Red Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-116) | BOS: (-102)
• Spread: NYY: -1.5 (+146) | BOS: +1.5 (-176)
• Total: 8.5 -- Over: (-106) | Under: (-114)

Yankees vs Red Sox Probable Starting Pitchers

Probable Pitchers: Luis Gil (Yankees) - 0-1, 7.00 ERA vs Connelly Early (Red Sox) - 1-0, 2.29 ERA

The Yankees will give the nod to Luis Gil (0-1, 7.00 ERA), who is eyeing win No. 1 on the season, and the Red Sox will counter with Connelly Early (1-0, 2.29 ERA). Gil has a record of 0-2-0 ATS in two starts with a spread this season. Gil's team is 1-1 this season when he starts and they're favored on the moneyline. The Red Sox are 1-3-0 ATS in Early's four starts with a set spread. The Red Sox have always been the moneyline underdog when Early starts this season.

Yankees vs Red Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (56.6%)

Yankees vs Red Sox Moneyline

• New York is a -116 favorite on the moneyline, while Boston is a -102 underdog at home.

Yankees vs Red Sox Spread

• The Red Sox are +1.5 on the run line against the Yankees. The Red Sox are -176 to cover, and the Yankees are +146.

Yankees vs Red Sox Over/Under

• The over/under for the Yankees versus Red Sox game on April 21 has been set at 8.5, with -106 odds on the over and -114 odds on the under.

Bet on New York Yankees vs. Boston Red Sox on FanDuel today!

Yankees vs Red Sox Betting Trends

• The Yankees have come away with 11 wins in the 19 contests they have been listed as the favorites in this season.
• New York has a record of 10-8 in contests when bookmakers favor them by -116 or more on the moneyline.
• The Yankees' games have gone over the total in eight of their 20 opportunities.
• The Yankees have posted a record of 10-10-0 against the spread this season.
• The Red Sox have been the underdog on the moneyline a total of three times this season, and they've lost all of those games.
• Boston has played in three games as a moneyline underdog with odds of -102 or longer without a win.
• The Red Sox have had an over/under set by oddsmakers 22 times, and have combined with opponents to go over the total in 12 of those games (12-10-0).
• The Red Sox have put together a 7-15-0 record ATS this season.

Yankees Player Leaders

• Ben Rice has 22 hits and an OBP of .476 to go with a slugging percentage of .800. All three of those stats are best among New York hitters this season. He has a .338 batting average, as well.
• Among all qualified batters in the majors, he is fourth in batting average, first in on-base percentage, and first in slugging.
• Rice hopes to build on a four-game hitting streak in this matchup. In his last five games he is batting .278 with four home runs, four walks and five RBIs.
• Aaron Judge is batting .232 with three doubles, nine home runs and 11 walks. He's slugging .598 with an on-base percentage of .330.
• Among qualifying batters, he ranks 113th in batting average, 87th in on-base percentage and 10th in slugging percentage.
• Cody Bellinger has 21 hits this season and has a slash line of .276/.380/.461.
• Bellinger heads into this matchup with eight games in a row with at least one hit. During his last 10 outings he is batting .289 with two doubles, two home runs, five walks and seven RBIs.
• Trent Grisham has been key for New York with 11 hits, an OBP of .321 plus a slugging percentage of .348.

Red Sox Player Leaders

• Wilyer Abreu has a slugging percentage of .481 and has 24 hits, both team-best numbers for the Red Sox. He's batting .296 and with an on-base percentage of .352.
• Including all qualifying hitters, he ranks 27th in batting average, while his on-base percentage is 67th and he is 45th in slugging.
• Willson Contreras has a .404 OBP to lead his team. He has a batting average of .274 while slugging .466.
• Including all qualifying hitters, his batting average places him 52nd, his on-base percentage ranks 14th, and he is 51st in slugging.
• Roman Anthony has three doubles, a triple, a home run and 15 walks while hitting .234.
• Ceddanne Rafaela is batting .286 with three doubles, a home run and four walks.

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