Yankees vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for March 25

Odds updated as of 6:12 a.m.

The New York Yankees and the San Francisco Giants meet for MLB Opening Day on Wednesday.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Yankees vs Giants Game Info

• New York Yankees (0-0) vs. San Francisco Giants (0-0)
• Date: Wednesday, March 25, 2026
• Time: 8:05 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: Netflix

Yankees vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-122) | SF: (+104)
• Spread: NYY: -1.5 (+146) | SF: +1.5 (-176)
• Total: 7 -- Over: (-102) | Under: (-120)

Yankees vs Giants Probable Starting Pitchers

Probable Pitchers: Max Fried (Yankees) - 0-0, 0.00 ERA vs Logan Webb (Giants) - 0-0, 0.00 ERA

The Yankees will call on Max Fried against the Giants and Logan Webb. In games Fried pitched with a spread last season, his team was 19-15-0 ATS. Fried and his team won as favorites in 64.7% of his 34 appearances last season with a moneyline. Last season Webb and his team finished 16-18-0 against the spread when he pitched. Webb and his team went 3-1 in games he appeared in when they were the underdog on the moneyline a season ago.

Yankees vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (51.3%)

Yankees vs Giants Moneyline

• The Yankees vs Giants moneyline has New York as a -122 favorite, while San Francisco is a +104 underdog at home.

Yankees vs Giants Spread

• The Giants are +1.5 on the run line against the Yankees. The Giants are -176 to cover, and the Yankees are +146.

Yankees vs Giants Over/Under

• A total of 7 runs has been set for the Yankees-Giants game on March 25, with the over available at -102 and the under at -120.

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Yankees vs Giants Betting Trends

• The Yankees were victorious in 88, or 61.5%, of the 143 contests they were chosen as favorites last season.
• Last season New York came away with a win 83 times in 133 chances when named as a favorite of at least -122 or shorter on the moneyline.
• The Yankees and their opponents hit the over in 79 of their 166 games with a total last season.
• The Giants finished 29-36 in games they were the underdog on the moneyline last season (winning 44.6% of those games).
• When it played as a moneyline underdog with odds of +104 or longer last year, San Francisco went 21-28 (42.9%).
• The Giants played in 161 games with a set over/under last season, and combined with their opponents to go over the total 77 times (77-76-8).

Yankees Player Leaders

• Aaron Judge had 179 base hits and an OBP of .457 to go with a slugging percentage of .688 last season.
• Cody Bellinger slashed .272/.334/.480 and finished with an OPS of .813.
• Last season, Trent Grisham finished with 34 home runs, 74 RBI and a batting average of .235 last season.
• Ben Rice slashed .255/.337/.499 and finished with an OPS of .836.

Giants Player Leaders

• Rafael Devers racked up an OBP of .372 with 153 hits last season.
• Luis Arraez slugged .392 while batting .292.
• Willy Adames had 22 doubles, two triples, 30 home runs and 80 walks while batting .225 last season.
• Jung Hoo Lee hit .266 with 31 doubles, 12 triples, eight home runs and 47 walks.

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