Tigers vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for April 4

Odds updated as of 8:12 p.m.

The Detroit Tigers will take on the St. Louis Cardinals in MLB action on Saturday.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Tigers vs Cardinals Game Info

• Detroit Tigers (3-4) vs. St. Louis Cardinals (4-3)
• Date: Saturday, April 4, 2026
• Time: 1:10 p.m. ET
• Venue: Comerica Park -- Detroit, Michigan
• Coverage: DSN and Cardinals.TV

Tigers vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-156) | STL: (+132)
• Spread: DET: -1.5 (+142) | STL: +1.5 (-172)
• Total: 7.5 -- Over: (-105) | Under: (-115)

Tigers vs Cardinals Probable Starting Pitchers

Probable Pitchers: Jack Flaherty (Tigers) - 0-1, 4.15 ERA vs Dustin May (Cardinals) - 0-1, 13.50 ERA

This contest's pitching matchup is set, as the Tigers will send Jack Flaherty (0-1) to the mound, while Dustin May (0-1) will answer the bell for the Cardinals. Flaherty and his team failed to cover the spread in his only opportunity this season as a starter. This will be Flaherty's first start this season with his team as the moneyline favorite. May has started only one game with a set spread, which the Cardinals failed to cover. The Cardinals were the moneyline underdog for one May start this season -- they lost.

Tigers vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (64.6%)

Tigers vs Cardinals Moneyline

• The Tigers vs Cardinals moneyline has Detroit as a -156 favorite, while St. Louis is a +132 underdog on the road.

Tigers vs Cardinals Spread

• The Tigers are 1.5-run home favorites on the runline against the Cardinals. The Tigers are +142 to cover, and the Cardinals are -172.

Tigers vs Cardinals Over/Under

• Tigers versus Cardinals, on April 4, has an over/under of 7.5, with the over being -105 and the under -115.

Bet on Detroit Tigers vs. St. Louis Cardinals on FanDuel today!

Tigers vs Cardinals Betting Trends

• The Tigers have been favorites in three games this season and have come away with the win two times (66.7%) in those contests.
• Detroit has played as a favorite of -156 or more just one time this year and came away with a win in that game.
• The Tigers and their opponents have gone over in three of their seven games with a total set by sportsbooks this season.
• The Tigers are 3-4-0 against the spread in their seven games with a line set by sportsbooks this season.
• The Cardinals have won four of the seven games they were the underdog on the moneyline this season (57.1%).
• St. Louis has played as a moneyline underdog of +132 or longer in only two games this season, which it split 1-1.
• In the seven games oddsmakers have set an over/under for the Cardinals, they have combined with opponents to go over the total three times (3-4-0).
• The Cardinals have put together a 4-3-0 record ATS this season.

Tigers Player Leaders

• Kevin McGonigle leads Detroit with a slugging percentage of .538, fueled by four extra-base hits. He has a .346 batting average and an on-base percentage of .414.
• Among qualified batters in baseball, his batting average ranks 26th, his on-base percentage ranks 27th, and he is 40th in slugging.
• McGonigle will look for his fourth straight game with a hit in this matchup. During his last five outings he is hitting .222 with a double, a triple, two walks and an RBI.
• Dillon Dingler has six hits, which is best among Detroit batters this season. He's batting .300 with three extra-base hits. He's also slugging .650 with an on-base percentage of .364.
• He is 50th in batting average, 73rd in on-base percentage and 20th in slugging among qualified hitters.
• Dingler has picked up at least one hit in three straight games. In his last five games he is batting .267 with a double, a home run, a walk and four RBIs.
• Riley Greene has collected seven base hits, an OBP of .290 and a slugging percentage of .345 this season.
• Greene has recorded at least one base hit in four straight games. During his last five outings he is batting .300 with three doubles, a walk and four RBIs.
• Colt Keith has been key for Detroit with eight hits, an OBP of .417 plus a slugging percentage of .545.
• Keith has safely hit in four games in a row. During his last five outings he is hitting .353 with four doubles, two walks and two RBIs.

Cardinals Player Leaders

• Alec Burleson has a team-high .387 on-base percentage. He's batting .280 and slugging .440.
• Including all the qualified players in MLB, his batting average ranks 62nd, his on-base percentage ranks 50th, and he is 72nd in slugging.
• JJ Wetherholt is batting .259 with a home run and two walks. He's slugging .370 with an on-base percentage of .300.
• Including all qualified hitters, his batting average places him 78th, his on-base percentage is 120th, and he is 105th in slugging.
• Jordan Walker is hitting .217 with two doubles, a home run and three walks.
• Nolan Gorman has racked up five hits to lead his team.

Tigers vs Cardinals Head to Head

• 4/3/2026: 4-0 DET (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 5/21/2025: 5-1 DET (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/20/2025: 5-4 DET (Favorite: Tigers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -176, Underdog Moneyline: +148)
• 5/19/2025: 11-4 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 5/1/2024: 4-1 DET (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/30/2024: 11-6 DET (Favorite: Tigers, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/30/2024: 2-1 STL (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/7/2023: 12-6 STL (Favorite: Cardinals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 5/6/2023: 6-5 DET (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 5/5/2023: 5-4 DET (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -240, Underdog Moneyline: +198)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!