Tigers vs Brewers Prediction, Odds, Moneyline, Spread & Over/Under for April 21

Odds updated as of 2:11 a.m.

The MLB's Tuesday slate includes the Detroit Tigers facing the Milwaukee Brewers.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Tigers vs Brewers Game Info

• Detroit Tigers (12-11) vs. Milwaukee Brewers (12-9)
• Date: Tuesday, April 21, 2026
• Time: 6:40 p.m. ET
• Venue: Comerica Park -- Detroit, Michigan
• Coverage: DSN and Brewers.TV

Tigers vs Brewers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-116) | MIL: (-102)
• Spread: DET: +1.5 (-205) | MIL: -1.5 (+168)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Tigers vs Brewers Probable Starting Pitchers

Probable Pitchers: Keider Montero (Tigers) - 1-1, 3.31 ERA vs Kyle Harrison (Brewers) - 1-1, 3.07 ERA

This contest's pitching matchup is set, as the Tigers will send Keider Montero (1-1) to the mound, while Kyle Harrison (1-1) will take the ball for the Brewers. Montero and his team have a record of 2-1-0 against the spread when he starts. Montero's team is 1-1 this season when he starts and they're favored on the moneyline. The Brewers have a 1-2-0 ATS record in Harrison's three starts that had a set spread. The Brewers were named the moneyline underdog for one Harrison start this season -- they won.

Tigers vs Brewers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (55.7%)

Tigers vs Brewers Moneyline

• Detroit is the favorite, -116 on the moneyline, while Milwaukee is a -102 underdog on the road.

Tigers vs Brewers Spread

• The Brewers are 1.5-run favorites against the spread for this matchup with the Tigers. The Brewers are +168 to cover, while the Tigers are -205 to cover as a 1.5-run underdog on the runline.

Tigers vs Brewers Over/Under

• The Tigers-Brewers contest on April 21 has been given an over/under of 8.5 runs. The over is set at -105 and the under at -115.

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Tigers vs Brewers Betting Trends

• The Tigers have been victorious in nine, or 64.3%, of the 14 contests they have been chosen as favorites in this season.
• Detroit has a record of 9-5 when favored by -116 or more this year.
• The Tigers and their opponents have gone over in 10 of their 23 games with a total set by sportsbooks this season.
• The Tigers have posted a record of 12-11-0 against the spread this season.
• The Brewers have put together a 3-4 record in games they were listed as the moneyline underdog (winning 42.9% of those games).
• Milwaukee has a 2-2 record (winning 50% of its games) when it has played as a moneyline underdog of -102 or longer.
• The Brewers have combined with opponents to hit the over on the total 12 times this season for a 12-9-0 record against the over/under.
• The Brewers have put together a 13-8-0 record ATS this season (covering 61.9% of the time).

Tigers Player Leaders

• Kevin McGonigle leads Detroit OPS (.898) this season. He has a .317 batting average, an on-base percentage of .411, and a slugging percentage of .488.
• Among all qualified hitters in MLB, his batting average ranks 13th, his on-base percentage ranks 13th, and he is 41st in slugging.
• McGonigle will look for his sixth straight game with a hit in this contest. In his last five games he is batting .333 with a double, a triple, two walks and an RBI.
• Dillon Dingler leads Detroit in total hits (19) this season while batting .284 with nine extra-base hits. He's slugging .567 with an on-base percentage of .368.
• He is 40th in batting average, 44th in on-base percentage and 15th in slugging in the major leagues.
• Riley Greene is batting .263 with a .388 slugging percentage and 14 RBI this year.
• Greene heads into this matchup with two games in a row with at least one hit. In his last five games he is batting .429 with three doubles, five walks and four RBIs.
• Gleyber Torres has one home run, seven RBI and a batting average of .238 this season.
• Torres has hit safely in three games in a row. In his last five games he is hitting .250 with a double, four walks and three RBIs.

Brewers Player Leaders

• Brice Turang has racked up a slugging percentage of .571 and has 21 hits, both team-best numbers for the Brewers. He's batting .300 and with an on-base percentage of .437.
• Including all qualified players, he ranks 23rd in batting average, while his on-base percentage is fifth and he is 14th in slugging.
• William Contreras paces his team with a .452 slugging percentage. He has a batting average of .288 with an on-base percentage of .381.
• His batting average ranks 35th among all qualified players, his on-base percentage ranks 28th, and he is 64th in slugging.
• Jake Bauers is batting .224 with a double, five home runs and seven walks.
• Gary Sanchez has a double, five home runs and 13 walks while batting .238.

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