Sabres vs Bruins NHL Prediction, Odds, Picks, Best Bets for NHL Playoffs First Round Game 2

The Tuesday slate in the NHL includes a matchup between the Buffalo Sabres and the Boston Bruins.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NHL betting insights.

Sabres vs Bruins Game Info

• Buffalo Sabres (50-23-9) vs. Boston Bruins (45-27-10)
• Date: Tuesday, April 21, 2026
• Time: 7:30 p.m. ET
• Venue: KeyBank Center -- Buffalo, New York
• Coverage: ESPN

Sabres vs Bruins Odds

All NHL odds, betting lines and prop bets are available on FanDuel Sportsbook.

Sabres vs Bruins Prediction & Pick

All NHL win probability predictions and picks are according to numberFire.

• Prediction: Sabres win (56.3%)

Sabres vs Bruins Puck Line

• The Bruins are underdogs by 1.5 goals (-172 to cover). And Buffalo, the favorite, is +138.

Sabres vs Bruins Over/Under

• Sabres versus Bruins on April 21 has an over/under of 6.5 goals, with the over +106 and the under -130.

Sabres vs Bruins Moneyline

• The moneyline numbers for Sabres vs. Bruins reveal Buffalo as the favorite (-170) and Boston as the underdog (+140) on the road.

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