Royals vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 10:11 p.m.

The Kansas City Royals will take on the Baltimore Orioles in MLB action on Wednesday.

All the info you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Royals vs Orioles Game Info

• Kansas City Royals (7-16) vs. Baltimore Orioles (11-12)
• Date: Wednesday, April 22, 2026
• Time: 2:10 p.m. ET
• Venue: Kauffman Stadium -- Kansas City, Missouri
• Coverage: Royals.TV and MASN

Royals vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: KC: (-124) | BAL: (+106)
• Spread: KC: -1.5 (+164) | BAL: +1.5 (-200)
• Total: 9 -- Over: (-122) | Under: (+100)

Royals vs Orioles Probable Starting Pitchers

Probable Pitchers: Michael Wacha (Royals) - 2-0, 1.00 ERA vs Chris Bassitt (Orioles) - 0-2, 6.19 ERA

This contest's pitching matchup is set, as the Royals will send Michael Wacha (2-0) to the mound, while Chris Bassitt (0-2) will get the nod for the Orioles. Wacha and his team are 2-2-0 ATS this season when he starts. Wacha's team won his only start as a favorite this season. The Orioles have gone 2-2-0 ATS in Bassitt's four starts with a set spread. The Orioles have a 2-1 record in Bassitt's three starts this season when they were the underdog on the moneyline.

Royals vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Royals win (56.4%)

Royals vs Orioles Moneyline

• Kansas City is the favorite, -124 on the moneyline, while Baltimore is a +106 underdog on the road.

Royals vs Orioles Spread

• The Royals are 1.5-run home favorites on the runline against the Orioles. The Royals are +164 to cover, and the Orioles are -200.

Royals vs Orioles Over/Under

• The Royals-Orioles game on April 22 has been given an over/under of 9 runs. The over is set at -122 and the under at +100.

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Royals vs Orioles Betting Trends

• The Royals have come away with four wins in the nine contests they have been listed as the favorites in this season.
• This year Kansas City has won three of six games when listed as at least -124 on the moneyline.
• The Royals and their opponents have hit the over in seven of their 21 games with a total set by oddsmakers this season.
• The Royals have posted a record of 8-13-0 against the spread this season.
• The Orioles have won 25% of the games this season they were the moneyline underdog (2-6).
• Baltimore is 1-3 (winning only 25% of its games) when it has played as a moneyline underdog of +106 or longer.
• In the 23 games bookmakers have set an over/under for the Orioles, they have combined with opponents to go over the total 13 times (13-10-0).
• The Orioles have a 9-14-0 record against the spread this season (covering just 39.1% of the time).

Royals Player Leaders

• Maikel Garcia leads Kansas City with a slugging percentage of .402, fueled by eight extra-base hits. He has a .272 batting average and an on-base percentage of .333.
• Among qualified batters in baseball, he ranks 55th in batting average, 83rd in on-base percentage, and 85th in slugging.
• Bobby Witt Jr. is slashing .287/.370/.356 this season and leads the Royals with an OPS of .726.
• Among qualifiers, he is 37th in batting average, 42nd in on-base percentage and 122nd in slugging percentage.
• Witt enters this game looking to extend his three-game hit streak. In his last five games he is hitting .400 with three doubles, two walks and two RBIs.
• Carter Jensen leads Kansas City with 15 hits. He is batting .238 this season and six of his hits have gone for extra bases.
• Jensen has recorded at least one base hit in two straight games. During his last five outings he is hitting .278 with a home run, three walks and three RBIs.
• Vinnie Pasquantino has two home runs, 11 RBI and a batting average of .149 this season.

Orioles Player Leaders

• Taylor Ward has a team-best OBP (.394) and slugging percentage (.457). He's batting .293.
• Including all the qualified hitters in the majors, his batting average ranks 30th, his on-base percentage ranks 17th, and he is 59th in slugging.
• Ward takes a three-game hitting streak into this game. During his last five outings he is batting .263 with two doubles, a home run, five walks and three RBIs.
• Gunnar Henderson has three doubles, a triple, seven home runs and 11 walks while batting .196. He's slugging .464 with an on-base percentage of .282.
• He is currently 156th in batting average, 146th in on-base percentage and 54th in slugging percentage among all qualified batters.
• Jeremiah Jackson has collected 21 hits, a team-high for the Orioles.
• Leody Taveras has three doubles, two home runs and nine walks while batting .341.

Royals vs Orioles Head to Head

• 4/20/2026: 7-5 BAL (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/4/2025: 11-6 KC (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/3/2025: 4-0 KC (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/2/2025: 3-0 BAL (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/6/2025: 4-1 KC (Favorite: Royals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/5/2025: 8-1 BAL (Favorite: Royals, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/4/2025: 8-2 KC (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 10/2/2024: 2-1 KC (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 10/1/2024: 1-0 KC (Favorite: Orioles, Spread: -1.5, Total: 7, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/21/2024: 5-0 BAL (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)

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