Reds vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for April 16

Odds updated as of 8:12 p.m.

MLB action on Thursday includes the Cincinnati Reds taking on the San Francisco Giants.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Reds vs Giants Game Info

• Cincinnati Reds (10-7) vs. San Francisco Giants (6-11)
• Date: Thursday, April 16, 2026
• Time: 12:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: Reds.TV and NBCS-BA

Reds vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-124) | SF: (+106)
• Spread: CIN: +1.5 (-205) | SF: -1.5 (+168)
• Total: 8.5 -- Over: (-115) | Under: (-105)

Reds vs Giants Probable Starting Pitchers

Probable Pitchers: Chase Burns (Reds) - 1-1, 3.31 ERA vs Landen Roupp (Giants) - 2-1, 3.24 ERA

This contest's pitching matchup is set, as the Reds will send Chase Burns (1-1) to the mound, while Landen Roupp (2-1) will answer the bell for the Giants. Burns' team is 1-2-0 against the spread this season in his starts. Burns' team is 1-1 this season when he starts and they're favored on the moneyline. The Giants have a 1-2-0 ATS record in Roupp's three starts that had a set spread. The Giants were named the moneyline underdog for two Roupp starts this season -- they won both.

Reds vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (53.3%)

Reds vs Giants Moneyline

• Cincinnati is a -124 favorite on the moneyline, while San Francisco is a +106 underdog on the road.

Reds vs Giants Spread

• The Giants are 1.5-run favorites against the spread for this matchup with the Reds. The Giants are +168 to cover, while the Reds are -205 to cover as a 1.5-run underdog on the runline.

Reds vs Giants Over/Under

• The over/under for Reds-Giants on April 16 is 8.5. The over is -115, and the under is -105.

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Reds vs Giants Betting Trends

• The Reds have been chosen as favorites in four games this year and have walked away with the win three times (75%) in those games.
• This year Cincinnati has won two of three games when listed as at least -124 on the moneyline.
• The Reds and their opponents have gone over in nine of their 17 games with a total set by sportsbooks this season.
• The Reds are 9-8-0 against the spread in their 17 games with a line set by sportsbooks this season.
• The Giants have been the moneyline underdog 13 total times this season. They've finished 5-8 in those games.
• San Francisco has a 2-4 record (winning just 33.3% of its games) when playing as a moneyline underdog of +106 or longer.
• The Giants have combined with opponents to hit the over on the total seven times this season for a 7-7-3 record against the over/under.
• The Giants have a 5-12-0 record against the spread this season.

Reds Player Leaders

• Sal Stewart leads Cincinnati with 18 hits and an OBP of .431 this season. He has a .310 batting average and a slugging percentage of .638.
• Among all qualifying batters in MLB, his batting average ranks 26th, his on-base percentage ranks 10th, and he is seventh in slugging.
• Stewart has picked up at least one hit in two straight games. During his last five outings he is batting .176 with two home runs, four walks and three RBIs.
• Elly De La Cruz has an OPS of .912, fueled by an OBP of .360 and a team-best slugging percentage of .552 this season. He's batting .284.
• Among qualified batters, his batting average places him 53rd, his on-base percentage 58th, and his slugging percentage 23rd.
• De La Cruz brings a five-game streak with at least one hit into this one. During his last five outings he is batting .400 with two doubles, two home runs, two walks and four RBIs.
• Matt McLain has 13 hits this season and has a slash line of .210/.338/.258.
• Spencer Steer is batting .185 with a .224 OBP and five RBI for Cincinnati this season.

Giants Player Leaders

• Willy Adames has 18 hits, a team-best for the Giants. He's batting .273 and slugging .545 with an on-base percentage of .324.
• Including all qualified players, he ranks 60th in batting average, while his on-base percentage is 101st and he is 26th in slugging.
• Luis Arraez has a .364 OBP while slugging .417. Both pace his team. He has a batting average of .333.
• His batting average ranks eighth among all qualified players, his on-base percentage is 52nd, and he is 76th in slugging.
• Matt Chapman has three doubles, a triple, a home run and five walks while hitting .273.
• Jung Hoo Lee is batting .207 with five doubles, a home run and five walks.

Reds vs Giants Head to Head

• 4/14/2026: 2-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/9/2025: 8-6 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/8/2025: 1-0 CIN (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/7/2025: 2-0 CIN (Favorite: Giants, Spread: -1.5, Total: 6.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 3/30/2025: 6-3 SF (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 3/29/2025: 3-2 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 3/27/2025: 6-4 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 8/4/2024: 8-2 SF (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/3/2024: 6-4 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/12/2024: 6-5 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -122, Underdog Moneyline: +104)

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