Rays vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 9:12 p.m.

The Tampa Bay Rays will face the Cincinnati Reds in MLB action on Wednesday.

All the information you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Rays vs Reds Game Info

• Tampa Bay Rays (12-10) vs. Cincinnati Reds (15-8)
• Date: Wednesday, April 22, 2026
• Time: 1:10 p.m. ET
• Venue: Tropicana Field -- St. Petersburg, Florida
• Coverage: Rays.TV and Reds.TV

Rays vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TB: (-126) | CIN: (+108)
• Spread: TB: -1.5 (+168) | CIN: +1.5 (-205)
• Total: 8 -- Over: (-105) | Under: (-115)

Rays vs Reds Probable Starting Pitchers

Probable Pitchers: Nick Martínez (Rays) - 0-1, 2.45 ERA vs Brandon Williamson (Reds) - 2-1, 4.35 ERA

The Rays will give the ball to Nick Martinez (0-1, 2.45 ERA), who is eyeing win No. 1 on the season, and the Reds will counter with Brandon Williamson (2-1, 4.35 ERA). Martínez's team is 3-1-0 against the spread in his starts this season. Martinez has yet to start a game this season when his team was the moneyline favorite. The Reds have a 3-1-0 record against the spread in Williamson's starts. The Reds are 2-1 in Williamson's three starts this season that they were the moneyline underdog.

Rays vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (59.4%)

Rays vs Reds Moneyline

• Tampa Bay is the favorite, -126 on the moneyline, while Cincinnati is a +108 underdog on the road.

Rays vs Reds Spread

• The Reds are at +1.5 on the runline against the Rays. The Reds are -205 to cover the spread, and the Rays are +168.

Rays vs Reds Over/Under

• A total of 8 runs has been set for the Rays-Reds game on April 22, with the over available at -105 and the under at -115.

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Rays vs Reds Betting Trends

• The Rays have won in six, or 54.5%, of the 11 contests they have been named as odds-on favorites in this year.
• This season Tampa Bay has come away with a win two times in four chances when named as a favorite of at least -126 on the moneyline.
• The Rays' games have gone over the total in 15 of their 22 opportunities.
• The Rays are 12-10-0 against the spread in their 22 games with a line set by sportsbooks this season.
• The Reds are 12-5 in games they were listed as the moneyline underdog (winning 70.6% of those games).
• Cincinnati is 8-3 (winning 72.7% of its games) when playing as a moneyline underdog of +108 or longer.
• In the 23 games oddsmakers have set an over/under for the Reds, they have combined with opponents to go over the total 12 times (12-10-1).
• The Reds have covered 60.9% of their games this season, going 14-9-0 against the spread.

Rays Player Leaders

• Yandy Diaz leads Tampa Bay with 28 hits and an OBP of .420 this season. He has a .326 batting average and a slugging percentage of .488.
• Among qualified hitters, he ranks ninth in batting average, his on-base percentage ranks eighth, and he is 41st in slugging.
• Junior Caminero has three doubles, five home runs and 12 walks. He's batting .250 and slugging .455 with an on-base percentage of .337.
• Among qualifying batters, he ranks 84th in batting average, 80th in on-base percentage and 61st in slugging percentage.
• Caminero brings a six-game streak with at least one hit into this contest. In his last 10 outings he is batting .286 with two doubles, three home runs, four walks and seven RBIs.
• Chandler Simpson has hit zero homers with a team-high .382 SLG this season.
• Simpson heads into this matchup with four games in a row with at least one hit. In his last five games he is hitting .231 with .
• Jonathan Aranda has three home runs, 16 RBI and a batting average of .225 this season.

Reds Player Leaders

• Sal Stewart has put up an on-base percentage of .388, a slugging percentage of .639, and has 24 hits, all club-highs for the Reds (while batting .289).
• Including all qualifying hitters, he ranks 34th in batting average, while his on-base percentage is 22nd and he is third in slugging.
• Elly De La Cruz leads his team with a .511 slugging percentage. He has a batting average of .261 with an on-base percentage of .333.
• His batting average ranks 70th among all qualified players, his on-base percentage is 83rd, and he is 31st in slugging.
• Eugenio Suarez is batting .256 with three doubles, three home runs and nine walks.
• Matt McLain has four doubles and 15 walks while batting .188.

Rays vs Reds Head to Head

• 4/20/2026: 6-1 CIN (Favorite: Rays, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/27/2025: 2-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 7/26/2025: 6-2 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/25/2025: 7-2 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/28/2024: 2-1 TB (Favorite: Reds, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/27/2024: 4-0 TB (Favorite: Rays, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/26/2024: 3-2 CIN (Favorite: Reds, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/19/2023: 8-0 TB (Favorite: Rays, Spread: -1.5, Total: 9.5, Favorite Moneyline: -260, Underdog Moneyline: +215)
• 4/18/2023: 10-0 TB (Favorite: Rays, Spread: -1.5, Total: 9.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/17/2023: 8-1 CIN (Favorite: Rays, Spread: -1.5, Total: 9.5, Favorite Moneyline: -154, Underdog Moneyline: +130)

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