Rays vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for April 21

Odds updated as of 2:12 a.m.

On Tuesday in MLB, the Tampa Bay Rays are playing the Cincinnati Reds.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Rays vs Reds Game Info

• Tampa Bay Rays (12-10) vs. Cincinnati Reds (15-8)
• Date: Tuesday, April 21, 2026
• Time: 6:40 p.m. ET
• Venue: Tropicana Field -- St. Petersburg, Florida
• Coverage: Rays.TV and Reds.TV

Rays vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TB: (-108) | CIN: (-108)
• Spread: TB: +1.5 (-200) | CIN: -1.5 (+164)
• Total: 7.5 -- Over: (+100) | Under: (-122)

Rays vs Reds Probable Starting Pitchers

Probable Pitchers: Steven Matz (Rays) - 3-0, 3.80 ERA vs Chase Burns (Reds) - 1-1, 2.42 ERA

The probable starters are Steven Matz (3-0) for the Rays and Chase Burns (1-1) for the Reds. Matz and his team have covered in each of the four games he's started with a spread this season. Matz has started three games with his team as the moneyline favorite and won each of them. The Reds have gone 1-3-0 ATS in Burns' four starts with a set spread. The Reds were named the moneyline underdog for one Burns start this season -- they won.

Rays vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (54.2%)

Rays vs Reds Moneyline

• Tampa Bay is the favorite, -108 on the moneyline, while Cincinnati is a -108 underdog on the road.

Rays vs Reds Spread

Rays vs Reds Over/Under

• A total of 7.5 runs has been set for the Rays-Reds contest on April 21, with the over available at +100 and the under at -122.

Bet on Tampa Bay Rays vs. Cincinnati Reds on FanDuel today!

Rays vs Reds Betting Trends

• The Rays have been favorites in 11 games this season and have come away with the win six times (54.5%) in those contests.
• Tampa Bay has a record of 6-5 in contests when oddsmakers favor them by -108 or more on the moneyline.
• The Rays and their opponents have hit the over in 15 of their 22 games with a total set by oddsmakers this season.
• The Rays are 12-10-0 against the spread in their 22 games with a line set by sportsbooks this season.
• The Reds are 12-5 in games they were the underdog on the moneyline (winning 70.6% of those games).
• Cincinnati has a record of 12-5 when playing as a moneyline underdog with odds of -108 or longer (70.6%).
• The Reds have played in 23 games with an over/under set, and have combined with their opponents to go over the total 12 times (12-10-1).
• The Reds have a 14-9-0 record against the spread this season.

Rays Player Leaders

• Yandy Diaz leads Tampa Bay with 28 hits and an OBP of .420 this season. He has a .326 batting average and a slugging percentage of .488.
• Among all qualifying batters, he is ninth in batting average, his on-base percentage ranks eighth, and he is 41st in slugging.
• Junior Caminero has three doubles, five home runs and 12 walks. He's batting .250 and slugging .455 with an on-base percentage of .337.
• Among qualified batters, his batting average ranks him 84th, his on-base percentage 80th, and his slugging percentage 61st.
• Caminero brings a six-game streak with at least one hit into this matchup. In his last 10 games he is hitting .286 with two doubles, three home runs, four walks and seven RBIs.
• Jonathan Aranda has 18 hits this season and has a slash line of .225/.343/.388.
• Chandler Simpson leads Tampa Bay in slugging percentage (.382) thanks to two extra-base hits.
• Simpson has hit safely in four straight games. In his last five games he is batting .231 with .

Reds Player Leaders

• Sal Stewart has put up a team-best OBP (.388) and slugging percentage (.639), while pacing the Reds in hits (24, while batting .289).
• He ranks 34th in batting average, 22nd in on-base percentage and third in slugging percentage among all qualified batters in the majors.
• Elly De La Cruz is slugging .511 to lead his team. He has a batting average of .261 with an on-base percentage of .333.
• His batting average is 70th among all qualified players, his on-base percentage is 83rd, and he is 31st in slugging.
• Eugenio Suarez is hitting .256 with three doubles, three home runs and nine walks.
• Matt McLain has four doubles and 15 walks while batting .188.

Rays vs Reds Head to Head

• 4/20/2026: 6-1 CIN (Favorite: Rays, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/27/2025: 2-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 7/26/2025: 6-2 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/25/2025: 7-2 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/28/2024: 2-1 TB (Favorite: Reds, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/27/2024: 4-0 TB (Favorite: Rays, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/26/2024: 3-2 CIN (Favorite: Reds, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/19/2023: 8-0 TB (Favorite: Rays, Spread: -1.5, Total: 9.5, Favorite Moneyline: -260, Underdog Moneyline: +215)
• 4/18/2023: 10-0 TB (Favorite: Rays, Spread: -1.5, Total: 9.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/17/2023: 8-1 CIN (Favorite: Rays, Spread: -1.5, Total: 9.5, Favorite Moneyline: -154, Underdog Moneyline: +130)

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