Padres vs Rockies Prediction, Odds, Moneyline, Spread & Over/Under for April 21

Odds updated as of 5:12 a.m.

The San Diego Padres will face the Colorado Rockies in MLB action on Tuesday.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Padres vs Rockies Game Info

• San Diego Padres (15-7) vs. Colorado Rockies (9-14)
• Date: Tuesday, April 21, 2026
• Time: 8:40 p.m. ET
• Venue: Coors Field -- Denver, Colorado
• Coverage: Rockies.TV and Padres.TV

Padres vs Rockies Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-142) | COL: (+120)
• Spread: SD: -1.5 (+104) | COL: +1.5 (-125)
• Total: 11.5 -- Over: (+100) | Under: (-122)

Padres vs Rockies Probable Starting Pitchers

Probable Pitchers: Randy Vasquez (Padres) - 1-0, 2.49 ERA vs TBA (Rockies)

The Padres will look to Randy Vasquez (1-0), while the Rockies' starting pitcher has not yet been announced. Vasquez and his team have covered in each of his four starts with a spread this season. Vasquez's team won his only start as a favorite this season.

Padres vs Rockies Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (68.2%)

Padres vs Rockies Moneyline

• San Diego is the favorite, -142 on the moneyline, while Colorado is a +120 underdog despite being at home.

Padres vs Rockies Spread

• The Padres are favored by 1.5 runs on the road against the Rockies. The Padres are +104 to cover the spread, while the Rockies are -125.

Padres vs Rockies Over/Under

• A combined run total of 11.5 has been set for Padres-Rockies on April 21, with the over at +100 and the under at -122.

Bet on San Diego Padres vs. Colorado Rockies on FanDuel today!

Padres vs Rockies Betting Trends

• The Padres have come away with seven wins in the nine contests they have been listed as the favorites in this season.
• San Diego has not lost in six games this year when favored by -142 or better on the moneyline.
• The Padres and their opponents have gone over the total this season in nine of their 22 opportunities.
• The Padres have an against the spread mark of 15-7-0 in 22 games with a line this season.
• The Rockies are 9-14 in games they were the underdog on the moneyline (winning 39.1% of those games).
• When playing as a moneyline underdog with odds of +120 or longer, Colorado has an 8-14 record (winning just 36.4% of its games).
• The Rockies have played in 23 games with a set over/under, and have combined with their opponents to go over the total nine times (9-14-0).
• The Rockies have a 14-9-0 record against the spread this season (covering 60.9% of the time).

Padres Player Leaders

• Xander Bogaerts leads San Diego OPS (.746) this season. He has a .266 batting average, an on-base percentage of .341, and a slugging percentage of .405.
• Among qualifying batters in MLB, he ranks 64th in batting average, 76th in on-base percentage, and 80th in slugging.
• Bogaerts has picked up at least one hit in two straight games. In his last five games he is hitting .250 with a home run, three walks and three RBIs.
• Ramon Laureano leads San Diego with 21 hits and a team-best slugging percentage of .506. He's batting .273 with an on-base percentage of .329.
• He is 54th in batting average, 93rd in on-base percentage and 33rd in slugging among qualifying batters.
• Jackson Merrill has 19 hits this season and has a slash line of .221/.272/.395.
• Fernando Tatis Jr. is batting .253 with a .340 OBP and 12 RBI for San Diego this season.
• Tatis enters this game on a two-game hitting streak. During his last five outings he is hitting .308 with three walks and five RBIs.

Rockies Player Leaders

• Mickey Moniak is hitting .273 with three doubles, six home runs and three walks. He's slugging .655 with an on-base percentage of .305.
• Moniak hopes to build on a five-game hitting streak in this matchup. In his last five games he is batting .333 with three doubles, a home run, two walks and three RBIs.
• T.J. Rumfield is hitting .253 with a double, a triple, three home runs and seven walks. He's slugging .405 with an on-base percentage of .310.
• He is currently 81st in batting average, 118th in on-base percentage and 80th in slugging percentage among all qualifying hitters.
• Troy Johnston has racked up 21 hits with a .375 on-base percentage and a .500 slugging percentage, all club-bests for the Rockies.
• Hunter Goodman is hitting .241 with four doubles, five home runs and six walks.

Padres vs Rockies Head to Head

• 4/12/2026: 7-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 4/11/2026: 9-5 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 4/10/2026: 5-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 4/9/2026: 7-3 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 9/14/2025: 9-6 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -310, Underdog Moneyline: +250)
• 9/13/2025: 11-3 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -375, Underdog Moneyline: +300)
• 9/12/2025: 4-2 COL (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -270, Underdog Moneyline: +220)
• 9/11/2025: 2-0 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -270, Underdog Moneyline: +220)
• 9/7/2025: 8-1 SD (Favorite: Padres, Spread: -1.5, Total: 11, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 9/6/2025: 10-8 SD (Favorite: Padres, Spread: -1.5, Total: 11.5, Favorite Moneyline: -190, Underdog Moneyline: +160)

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