NFL Games This Week: Predictions, Odds, Picks, Best Bets for Wild Card Round

The NFL Playoffs Wild Card slate has plenty of quality competition in store. Among those games is the Buffalo Bills playing the Jacksonville Jaguars.

There is NFL action this week, and we've got you covered with the betting odds you need to get an edge.

Panthers vs. Rams

The NFC Wild Card round of the NFL Playoffs will see the Carolina Panthers (8-9) and Los Angeles Rams (12-5) clash at Bank of America Stadium on Jan. 10 at 4:30 p.m. ET.

• Game Preview: Los Angeles Rams at Carolina Panthers
• Projected Favorite: Rams (77.76% win probability)
• Spread: Los Angeles (-10.5)
• Total: 46.5 -- Over: (-105) | Under: (-115)
• Time: 4:30 p.m. ET
• Channel: FOX

Bet on Carolina vs. Los Angeles with FanDuel Sportsbook.

Bears vs. Packers

In the NFC Wild Card round of the NFL Playoffs, the Chicago Bears (11-6) and Green Bay Packers (9-7-1) take the field on Saturday, January 10, 2026 at Soldier Field.

• Game Preview: Green Bay Packers at Chicago Bears
• Projected Favorite: Bears (54.40% win probability)
• Spread: Green Bay (-1.5)
• Total: 44.5 -- Over: (-115) | Under: (-105)
• Time: 8 p.m. ET
• Channel: Amazon Prime Video

Bet on Chicago vs. Green Bay with FanDuel Sportsbook.

Jaguars vs. Bills

The Jacksonville Jaguars (13-4) play at home in a playoff matchup with the Buffalo Bills (12-5) at EverBank Stadium in the AFC Wild Card round on Jan. 11 at 1 p.m. ET.

• Game Preview: Buffalo Bills at Jacksonville Jaguars
• Projected Favorite: Jaguars (60.26% win probability)
• Spread: Buffalo (-1.5)
• Total: 51.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Jacksonville vs. Buffalo with FanDuel Sportsbook.

Eagles vs. 49ers

The San Francisco 49ers (12-5) square off against the Philadelphia Eagles (11-6) in the NFC Wild Card round of the playoffs at Lincoln Financial Field on Sunday, January 11, 2026.

• Game Preview: San Francisco 49ers at Philadelphia Eagles
• Projected Favorite: Eagles (65.69% win probability)
• Spread: Philadelphia (-4.5)
• Total: 44.5 -- Over: (-105) | Under: (-115)
• Time: 4:30 p.m. ET
• Channel: FOX

Bet on Philadelphia vs. San Francisco with FanDuel Sportsbook.

Patriots vs. Chargers

The Los Angeles Chargers (11-6) will try to go on the road and win in the playoffs against the New England Patriots (14-3) in the AFC Wild Card round on Jan. 11 at 8 p.m. ET at Gillette Stadium.

• Game Preview: Los Angeles Chargers at New England Patriots
• Projected Favorite: Patriots (71.89% win probability)
• Spread: New England (-3.5)
• Total: 46.5 -- Over: (-104) | Under: (-118)
• Time: 8 p.m. ET
• Channel: NBC/Peacock

Bet on New England vs. Los Angeles with FanDuel Sportsbook.

Steelers vs. Texans

The Pittsburgh Steelers (10-7) and Houston Texans (12-5) meet in the AFC Wild Card round of the NFL Playoffs at Acrisure Stadium on Monday, January 12, 2026.

• Game Preview: Houston Texans at Pittsburgh Steelers
• Projected Favorite: Steelers (55.56% win probability)
• Spread: Houston (-3)
• Total: 38.5 -- Over: (-110) | Under: (-110)
• Time: 8:15 p.m. ET
• Channel: ABC/ESPN

Bet on Pittsburgh vs. Houston with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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