NFL Games This Week: Predictions, Odds, Picks, Best Bets for Divisional Round

The NFL Playoffs Divisional slate has plenty of exciting matchups in store. Among those games is the San Francisco 49ers playing the Seattle Seahawks.

For a breakdown of all the important matchups in the NFL this weekend, check out our betting odds preview below.

Broncos vs. Bills

The Buffalo Bills (12-5) go on the road in a playoff matchup with the Denver Broncos (14-3) at Empower Field at Mile High in the AFC Divisional round on Jan. 17 at 4:30 p.m. ET.

• Game Preview: Buffalo Bills at Denver Broncos
• Projected Favorite: Broncos (64.04% win probability)
• Spread: Denver (-1.5)
• Total: 46.5 -- Over: (-105) | Under: (-115)
• Time: 4:30 p.m. ET

Bet on Denver vs. Buffalo with FanDuel Sportsbook.

Seahawks vs. 49ers

The San Francisco 49ers (12-5) hit the road in the playoffs against the Seattle Seahawks (14-3) in the NFC Divisional round on Saturday, January 17, 2026 at Lumen Field.

• Game Preview: San Francisco 49ers at Seattle Seahawks
• Projected Favorite: Seahawks (58.28% win probability)
• Spread: Seattle (-7)
• Total: 44.5 -- Over: (-118) | Under: (-104)
• Time: 8 p.m. ET
• Channel: FOX

Bet on Seattle vs. San Francisco with FanDuel Sportsbook.

Patriots vs. Texans

A playoff matchup pits the Houston Texans (12-5) against the New England Patriots (14-3) in the AFC Divisional round on Jan. 18 at 3 p.m. ET at Gillette Stadium.

• Game Preview: Houston Texans at New England Patriots
• Projected Favorite: Patriots (68.57% win probability)
• Spread: New England (-3)
• Total: 40.5 -- Over: (-115) | Under: (-105)
• Time: 3 p.m. ET
• Channel: ABC/ESPN

Bet on New England vs. Houston with FanDuel Sportsbook.

Bears vs. Rams

The Chicago Bears (11-6) meet the Los Angeles Rams (12-5) in the NFC Divisional round of the playoffs at Soldier Field on Sunday, January 18, 2026.

• Game Preview: Los Angeles Rams at Chicago Bears
• Projected Favorite: Rams (63.73% win probability)
• Spread: Los Angeles (-3.5)
• Total: 48.5 -- Over: (-110) | Under: (-110)
• Time: 6:30 p.m. ET
• Channel: NBC/Peacock

Bet on Chicago vs. Los Angeles with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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