Wednesday’s MLB Odds, Betting Lines and Predictions - April 22

In a Wednesday MLB schedule that includes a lot of compelling matchups, the Pittsburgh Pirates versus the Texas Rangers is a game to watch. For predictions on every game on the slate, see the article below.

Today's MLB Odds and Predictions

St. Louis Cardinals at Miami Marlins Odds, Lines & Predictions

Game Info

• When: 12:10 p.m. ET
• Where: loanDepot park
• TV Channel: MIAM and CARD
• Probable Pitchers: Janson Junk vs. Kyle Leahy
• Records: Marlins (11-13), Cardinals (14-9)
• Marlins Moneyline Odds: -142
• Cardinals Moneyline Odds: +120

numberFire Prediction

• numberFire Predicted Favorite: Marlins
• Marlins Win Probability: 57.42%
• Cardinals Win Probability: 42.58%

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Houston Astros at Cleveland Guardians Odds, Lines & Predictions

Game Info

• When: 1:10 p.m. ET
• Where: Progressive Field
• TV Channel: CLEG and SCHN
• Probable Pitchers: Tanner Bibee vs. Peter Lambert
• Records: Guardians (14-11), Astros (9-16)
• Guardians Moneyline Odds: -138
• Astros Moneyline Odds: +118

numberFire Prediction

• numberFire Predicted Favorite: Guardians
• Guardians Win Probability: 50.40%
• Astros Win Probability: 49.60%

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Cincinnati Reds at Tampa Bay Rays Odds, Lines & Predictions

Game Info

• When: 1:10 p.m. ET
• Where: Tropicana Field
• TV Channel: RAYS and CINR
• Probable Pitchers: Nick Martínez vs. Brandon Williamson
• Records: Rays (12-11), Reds (16-8)
• Rays Moneyline Odds: -138
• Reds Moneyline Odds: +118

numberFire Prediction

• numberFire Predicted Favorite: Rays
• Rays Win Probability: 58.05%
• Reds Win Probability: 41.95%

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Baltimore Orioles at Kansas City Royals Odds, Lines & Predictions

Game Info

• When: 2:10 p.m. ET
• Where: Kauffman Stadium
• TV Channel: ROYL and MASN
• Probable Pitchers: Michael Wacha vs. Chris Bassitt
• Records: Royals (8-16), Orioles (11-13)
• Royals Moneyline Odds: -130
• Orioles Moneyline Odds: +110

numberFire Prediction

• numberFire Predicted Favorite: Royals
• Royals Win Probability: 56.40%
• Orioles Win Probability: 43.60%

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Toronto Blue Jays at Los Angeles Angels Odds, Lines & Predictions

Game Info

• When: 3:07 p.m. ET
• Where: Angel Stadium
• TV Channel: FDSW and SNET
• Probable Pitchers: José Soriano vs. Eric Lauer
• Records: Angels (11-14), Blue Jays (10-13)
• Angels Moneyline Odds: -158
• Blue Jays Moneyline Odds: +134

numberFire Prediction

• numberFire Predicted Favorite: Blue Jays
• Blue Jays Win Probability: 52.97%
• Angels Win Probability: 47.03%

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Athletics at Seattle Mariners Odds, Lines & Predictions

Game Info

• When: 4:10 p.m. ET
• Where: T-Mobile Park
• TV Channel: SEAM and NBCS-CA
• Probable Pitchers: Logan Gilbert vs. Aaron Civale
• Records: Mariners (10-15), Athletics (13-11)
• Mariners Moneyline Odds: -196
• Athletics Moneyline Odds: +164

numberFire Prediction

• numberFire Predicted Favorite: Mariners
• Mariners Win Probability: 60.89%
• Athletics Win Probability: 39.11%

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Milwaukee Brewers at Detroit Tigers Odds, Lines & Predictions

Game Info

• When: 6:40 p.m. ET
• Where: Comerica Park
• TV Channel: DSN and BREW
• Probable Pitchers: Casey Mize vs. Chad Patrick
• Records: Tigers (12-12), Brewers (13-9)
• Tigers Moneyline Odds: -134
• Brewers Moneyline Odds: +116

numberFire Prediction

• numberFire Predicted Favorite: Brewers
• Brewers Win Probability: 52.10%
• Tigers Win Probability: 47.90%

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Atlanta Braves at Washington Nationals Odds, Lines & Predictions

Game Info

• When: 6:45 p.m. ET
• Where: Nationals Park
• TV Channel: NATS and BravesVsn
• Probable Pitchers: Zack Littell vs. Martín Pérez
• Records: Nationals (11-13), Braves (16-8)
• Braves Moneyline Odds: -154
• Nationals Moneyline Odds: +130

numberFire Prediction

• numberFire Predicted Favorite: Braves
• Braves Win Probability: 56.43%
• Nationals Win Probability: 43.57%

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New York Yankees at Boston Red Sox Odds, Lines & Predictions

Game Info

• When: 6:45 p.m. ET
• Where: Fenway Park
• TV Channel: MLB Network and NESN and Amazon Prime Video
• Probable Pitchers: Ranger Suarez vs. Max Fried
• Records: Red Sox (9-14), Yankees (14-9)
• Yankees Moneyline Odds: -146
• Red Sox Moneyline Odds: +124

numberFire Prediction

• numberFire Predicted Favorite: Yankees
• Yankees Win Probability: 51.08%
• Red Sox Win Probability: 48.92%

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Minnesota Twins at New York Mets Odds, Lines & Predictions

Game Info

• When: 7:10 p.m. ET
• Where: Citi Field
• TV Channel: SNY and MNNT
• Probable Pitchers: Clay Holmes vs. Connor Prielipp
• Records: Mets (7-16), Twins (12-11)
• Mets Moneyline Odds: -158
• Twins Moneyline Odds: +134

numberFire Prediction

• numberFire Predicted Favorite: Mets
• Mets Win Probability: 61.95%
• Twins Win Probability: 38.05%

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Philadelphia Phillies at Chicago Cubs Odds, Lines & Predictions

Game Info

• When: 7:40 p.m. ET
• Where: Wrigley Field
• TV Channel: MARQ and NBCS-PH+
• Probable Pitchers: Matthew Boyd vs. Kyle Backhus
• Records: Cubs (14-9), Phillies (8-15)
• Cubs Moneyline Odds: -174
• Phillies Moneyline Odds: +146

numberFire Prediction

• numberFire Predicted Favorite: Cubs
• Cubs Win Probability: 63.60%
• Phillies Win Probability: 36.40%

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Pittsburgh Pirates at Texas Rangers Odds, Lines & Predictions

Game Info

• When: 8:05 p.m. ET
• Where: Globe Life Field
• TV Channel: RSN and SportsNet PT+
• Probable Pitchers: Jack Leiter vs. Braxton Ashcraft
• Records: Rangers (12-11), Pirates (13-10)
• Rangers Moneyline Odds: -108
• Pirates Moneyline Odds: -108

numberFire Prediction

• numberFire Predicted Favorite: Rangers
• Rangers Win Probability: 51.76%
• Pirates Win Probability: 48.24%

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San Diego Padres at Colorado Rockies Odds, Lines & Predictions

Game Info

• When: 8:40 p.m. ET
• Where: Coors Field
• TV Channel: COLR and SDPA
• Probable Pitchers: Tomoyuki Sugano vs. Walker Buehler
• Records: Rockies (9-15), Padres (16-7)
• Padres Moneyline Odds: -162
• Rockies Moneyline Odds: +136

numberFire Prediction

• numberFire Predicted Favorite: Padres
• Padres Win Probability: 66.52%
• Rockies Win Probability: 33.48%

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Chicago White Sox at Arizona Diamondbacks Odds, Lines & Predictions

Game Info

• When: 9:40 p.m. ET
• Where: Chase Field
• TV Channel: ARID and CHSN
• Probable Pitchers: Eduardo Rodríguez vs. Anthony Kay
• Records: Diamondbacks (13-10), White Sox (9-14)
• Diamondbacks Moneyline Odds: -152
• White Sox Moneyline Odds: +128

numberFire Prediction

• numberFire Predicted Favorite: Diamondbacks
• Diamondbacks Win Probability: 65.00%
• White Sox Win Probability: 35.00%

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Los Angeles Dodgers at San Francisco Giants Odds, Lines & Predictions

Game Info

• When: 9:45 p.m. ET
• Where: Oracle Park
• TV Channel: NBCS-BA and SportsNet LA
• Probable Pitchers: Tyler Mahle vs. Shohei Ohtani
• Records: Giants (10-13), Dodgers (16-7)
• Dodgers Moneyline Odds: -210
• Giants Moneyline Odds: +176

numberFire Prediction

• numberFire Predicted Favorite: Dodgers
• Dodgers Win Probability: 60.15%
• Giants Win Probability: 39.85%

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All MLB win probability predictions and picks are according to numberFire.