Marlins vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 12:11 p.m.

MLB action on Wednesday includes the Miami Marlins playing the St. Louis Cardinals.

We've got you covered, in terms of the vital information regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Marlins vs Cardinals Game Info

• Miami Marlins (11-13) vs. St. Louis Cardinals (14-9)
• Date: Wednesday, April 22, 2026
• Time: 12:10 p.m. ET
• Venue: loanDepot park -- Miami, Florida
• Coverage: Marlins.TV and Cardinals.TV

Marlins vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIA: (-136) | STL: (+116)
• Spread: MIA: -1.5 (+146) | STL: +1.5 (-178)
• Total: 8.5 -- Over: (+100) | Under: (-122)

Marlins vs Cardinals Probable Starting Pitchers

Probable Pitchers: Janson Junk (Marlins) - 0-2, 4.50 ERA vs Kyle Leahy (Cardinals) - 2-2, 5.21 ERA

The probable starters are Janson Junk (0-2) for the Marlins and Kyle Leahy (2-2) for the Cardinals. Junk's team is 1-3-0 against the spread in his starts this season. Junk's team is 1-1 this season when he starts and they're favored on the moneyline. The Cardinals have gone 2-2-0 against the spread when Leahy starts. The Cardinals are 2-2 in Leahy's four starts this season that they were the underdog on the moneyline.

Marlins vs Cardinals Moneyline

• Looking at the moneyline for Marlins-Cardinals, Miami is the favorite at -136, and St. Louis is +116 playing on the road.

Marlins vs Cardinals Spread

• The Marlins are hosting the Cardinals and are favored by 1.5 runs (+146 to cover) on the runline. St. Louis is -178 to cover.

Marlins vs Cardinals Over/Under

• A combined run total of 8.5 has been set for Marlins-Cardinals on April 22, with the over at +100 and the under at -122.

Bet on Miami Marlins vs. St. Louis Cardinals on FanDuel today!

Marlins vs Cardinals Betting Trends

• The Marlins have been victorious in nine, or 64.3%, of the 14 contests they have been chosen as favorites in this season.
• This season Miami has been victorious five times in seven chances when named as a favorite of at least -136 on the moneyline.
• The Marlins and their opponents have gone over the total this season in 13 of their 23 opportunities.
• The Marlins have posted a record of 8-15-0 against the spread this season.
• The Cardinals have compiled a 12-8 record in games they were the underdog on the moneyline (winning 60% of those games).
• When it has played as a moneyline underdog with odds of +116 or longer, St. Louis has gone 5-4 (55.6%).
• The Cardinals have had an over/under set by bookmakers 23 times, and have combined with opponents to go over the total in 13 of those games (13-9-1).
• The Cardinals have gone 13-10-0 ATS this season.

Marlins Player Leaders

• Liam Hicks leads Miami in total hits (24) this season while batting .324 with seven extra-base hits. He has an on-base percentage of .373 and a slugging percentage of .527.
• Among all qualifying hitters in baseball, his batting average ranks sixth, his on-base percentage ranks 33rd, and he is 24th in slugging.
• Xavier Edwards has a slash line of .348/.431/.483 this season and a team-best OPS of .915.
• Among qualifiers, he ranks third in batting average, fifth in on-base percentage and 41st in slugging percentage.
• Edwards heads into this game looking to extend his six-game hit streak. During his last 10 games he is batting .297 with two doubles, eight walks and an RBI.
• Otto Lopez has 28 hits this season and has a slash line of .318/.371/.523.
• Jakob Marsee is batting .176 with a .303 OBP and five RBI for Miami this season.

Cardinals Player Leaders

• Jordan Walker has put up a team-high slugging percentage (.607) and leads the Cardinals in hits (26). He's batting .292 and with an on-base percentage of .357.
• Including all qualifying hitters in the majors, his batting average puts him 26th, his on-base percentage is 54th, and he is sixth in slugging.
• Alec Burleson is hitting .278 with six doubles, three home runs and 12 walks. He's slugging .444 with an on-base percentage of .359.
• He is currently 41st in batting average, 52nd in on-base percentage and 62nd in slugging percentage among all qualifying batters.
• JJ Wetherholt has two doubles, three home runs and 15 walks while hitting .229.
• Ivan Herrera leads his team with a .383 OBP.

Marlins vs Cardinals Head to Head

• 4/21/2026: 5-3 STL (Favorite: Marlins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/20/2026: 5-3 MIA (Favorite: Marlins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 8/20/2025: 6-2 MIA (Favorite: Marlins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/19/2025: 7-4 STL (Favorite: Marlins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 8/18/2025: 8-3 STL (Favorite: Marlins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/30/2025: 2-0 MIA (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 7/29/2025: 5-0 MIA (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 7/28/2025: 7-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/19/2024: 4-3 MIA (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/18/2024: 9-8 MIA (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)

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