Guardians vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for April 18

Odds updated as of 2:12 a.m.

The MLB's Saturday slate includes the Cleveland Guardians taking on the Baltimore Orioles.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs Orioles Game Info

• Cleveland Guardians (11-10) vs. Baltimore Orioles (10-10)
• Date: Saturday, April 18, 2026
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and MASN

Guardians vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-126) | BAL: (+108)
• Spread: CLE: -1.5 (+176) | BAL: +1.5 (-215)
• Total: 7.5 -- Over: (-106) | Under: (-114)

Guardians vs Orioles Probable Starting Pitchers

Probable Pitchers: Gavin Williams (Guardians) - 2-1, 2.38 ERA vs Dean Kremer (Orioles) - 0-0, 3.60 ERA

The probable pitchers are Gavin Williams (2-1) for the Guardians and Dean Kremer for the Orioles. Williams' team is 3-1-0 against the spread this season in his starts. Williams' team is 2-0 this season when he starts and they're favored on the moneyline. Kremer has started just one game with a set spread, which the Orioles covered. The Orioles have not been a moneyline underdog when Kremer starts this season.

Guardians vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Orioles win (50.3%)

Guardians vs Orioles Moneyline

• The moneyline numbers for Guardians vs. Orioles reveal Cleveland as the favorite (-126) and Baltimore as the underdog (+108) on the road.

Guardians vs Orioles Spread

• The Orioles are at the Guardians, and are +1.5 on the runline. The Orioles are +176 to cover the spread, and the Guardians are -215.

Guardians vs Orioles Over/Under

• The over/under for Guardians-Orioles on April 18 is 7.5. The over is -106, and the under is -114.

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Guardians vs Orioles Betting Trends

• The Guardians have been victorious in three of the six contests they have been chosen as favorites in this season.
• This year Cleveland has won one of three games when listed as at least -126 on the moneyline.
• Contests with the Guardians have gone over the total set by bookmakers in 10 of 21 chances this season.
• In 21 games with a line this season, the Guardians have a mark of 12-9-0 against the spread.
• The Orioles have gone 2-4 in games they were listed as the moneyline underdog (winning 33.3% of those games).
• Baltimore has played as a moneyline underdog of +108 or longer in only two games this season, which it split 1-1.
• The Orioles have combined with opponents to go over the total 11 times this season for an 11-9-0 record against the over/under.
• The Orioles have collected an 8-12-0 record against the spread this season (covering 40% of the time).

Guardians Player Leaders

• Jose Ramirez leads Cleveland with an OBP of .348 this season while batting .221 with 15 walks and 12 runs scored. He has a slugging percentage of .429.
• Among qualified hitters in the majors, his batting average ranks 124th, his on-base percentage ranks 65th, and he is 75th in slugging.
• Chase DeLauter leads Cleveland in total hits (16) this season while batting .246 with 10 extra-base hits. He's slugging .554 with an on-base percentage of .342.
• Among all qualified, he ranks 91st in batting average, 75th in on-base percentage and 19th in slugging percentage.
• Steven Kwan has an OPS of .659, fueled by an OBP of .330 and a team-best slugging percentage of .329 this season.
• Kwan brings a three-game hitting streak into this matchup. In his last five games he is hitting .273 with a double, a walk and three RBIs.
• Angel Martinez has been key for Cleveland with 17 hits, an OBP of .333 plus a slugging percentage of .443.

Orioles Player Leaders

• Gunnar Henderson has three doubles, a triple, six home runs and eight walks while batting .200. He's slugging .471 with an on-base percentage of .274.
• Including all qualifying hitters, he is 147th in batting average, while his on-base percentage is 156th and he is 53rd in slugging.
• Taylor Ward paces his team with a .394 OBP, and has a club-leading .418 slugging percentage. He has a batting average of .291.
• Including all qualified hitters, he is 36th in batting average, 26th in on-base percentage and 79th in slugging percentage.
• Jeremiah Jackson has collected 19 hits, a team-high for the Orioles.
• Pete Alonso has five doubles, two home runs and 13 walks while batting .216.

Guardians vs Orioles Head to Head

• 4/17/2026: 6-4 BAL (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/16/2026: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/24/2025: 4-3 BAL (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/23/2025: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/22/2025: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/21/2025: 10-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 4/17/2025: 6-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/16/2025: 9-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/15/2025: 6-3 CLE (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 8/4/2024: 9-5 BAL (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)

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