Guardians vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 9:11 p.m.

The Cleveland Guardians versus the Houston Astros is on the MLB schedule for Wednesday.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Astros Game Info

• Cleveland Guardians (13-11) vs. Houston Astros (9-15)
• Date: Wednesday, April 22, 2026
• Time: 1:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and SCHN

Guardians vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-130) | HOU: (+110)
• Spread: CLE: -1.5 (+168) | HOU: +1.5 (-205)
• Total: 8 -- Over: (-105) | Under: (-115)

Guardians vs Astros Probable Starting Pitchers

Probable Pitchers: Tanner Bibee (Guardians) - 0-2, 4.81 ERA vs Peter Lambert (Astros) - 0-1, 7.20 ERA

The Guardians will give the nod to Tanner Bibee (0-2, 4.81 ERA), who is eyeing win No. 1 on the season, and the Astros will turn to Peter Lambert (0-1, 7.20 ERA). Bibee's team is 1-4-0 against the spread in his starts this season. Bibee's team is 0-2 this season when he starts and they're favored on the moneyline. Lambert has started just one game with a set spread, which the Astros failed to cover. The Astros have always been the moneyline underdog when Lambert starts this season.

Guardians vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (50.7%)

Guardians vs Astros Moneyline

• The Guardians vs Astros moneyline has Cleveland as a -130 favorite, while Houston is a +110 underdog on the road.

Guardians vs Astros Spread

• The Guardians are 1.5-run home favorites on the runline against the Astros. The Guardians are +168 to cover, and the Astros are -205.

Guardians vs Astros Over/Under

• An over/under of 8 has been set for Guardians-Astros on April 22, with the over being -105 and the under -115.

Bet on Cleveland Guardians vs. Houston Astros on FanDuel today!

Guardians vs Astros Betting Trends

• The Guardians have come away with five wins in the nine contests they have been listed as the favorites in this season.
• Cleveland has a record of 2-2 when favored by -130 or more this year.
• The Guardians and their opponents have hit the over in 12 of their 24 games with a total set by oddsmakers this season.
• The Guardians have posted a record of 14-10-0 against the spread this season.
• The Astros have compiled a 3-4 record in games they were listed as the moneyline underdog (winning 42.9% of those games).
• Houston has a 1-4 record (winning only 20% of its games) when playing as a moneyline underdog of +110 or longer.
• The Astros have combined with opponents to go over the total 17 times this season for a 17-7-0 record against the over/under.
• The Astros have put together a 9-15-0 record ATS this season (covering only 37.5% of the time).

Guardians Player Leaders

• Jose Ramirez leads Cleveland in slugging percentage (.494) and total hits (20) this season. He's batting .230 with an on-base percentage of .356.
• Among all qualifying hitters in baseball, he is 115th in batting average, 63rd in on-base percentage, and 38th in slugging.
• Ramirez will look for his third straight game with a hit in this contest. During his last five outings he is batting .357 with a double, three home runs, seven walks and four RBIs.
• Chase DeLauter is hitting .219 with five doubles, five home runs and 11 walks, while slugging .493 with an on-base percentage of .318.
• Among qualifiers, he ranks 129th in batting average, 108th in on-base percentage and 39th in slugging percentage.
• Brayan Rocchio has a team-best OPS of .847, fueled by a slash line of .286/.390/.457 this season.
• Rocchio heads into this matchup with seven games in a row with at least one hit. During his last 10 games he is batting .364 with two doubles, two home runs, four walks and eight RBIs.
• Steven Kwan leads Cleveland with a slugging percentage of .286, fueled by four extra-base hits.

Astros Player Leaders

• Yordan Alvarez has put up an on-base percentage of .459, a slugging percentage of .756, and has 28 hits, all club-highs for the Astros (while batting .326).
• Including all the qualifying hitters in the majors, his batting average ranks ninth, his on-base percentage is second, and he is second in slugging.
• Alvarez heads into this game on a seven-game hitting streak. During his last 10 outings he is batting .310 with four doubles, five home runs, five walks and eight RBIs.
• Christian Walker is batting .274 with seven doubles, five home runs and 12 walks. He's slugging .536 with an on-base percentage of .367.
• He ranks 52nd in batting average, 45th in on-base percentage and 22nd in slugging percentage in the majors.
• Jose Altuve is batting .281 with six doubles, three home runs and 15 walks.
• Carlos Correa is hitting .275 with five doubles, a home run and 11 walks.

Guardians vs Astros Head to Head

• 4/20/2026: 9-2 HOU (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/9/2025: 4-2 CLE (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 7/8/2025: 10-6 CLE (Favorite: Astros, Spread: -1.5, Total: 7, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 7/7/2025: 7-5 CLE (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/8/2025: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/7/2025: 5-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/6/2025: 4-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/28/2024: 4-3 HOU (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/27/2024: 5-2 HOU (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/2/2024: 8-2 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)

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