Giants vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for March 31

Odds updated as of 5:14 a.m.

The MLB schedule on Tuesday includes the San Francisco Giants taking on the San Diego Padres.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info regarding this matchup.

Giants vs Padres Game Info

• San Francisco Giants (1-3) vs. San Diego Padres (1-3)
• Date: Tuesday, March 31, 2026
• Time: 9:40 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and NBCS-BA

Giants vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-144) | SD: (+122)
• Spread: SF: -1.5 (+122) | SD: +1.5 (-146)
• Total: 7.5 -- Over: (-118) | Under: (-104)

Giants vs Padres Probable Starting Pitchers

Probable Pitchers: Logan Webb (Giants) - 0-1, 10.80 ERA vs German Marquez (Padres) - 0-0, 0.00 ERA

The Giants will call on Logan Webb against the Padres and German Marquez. Webb and his team failed to cover the spread in his only opportunity this season as a starter. This will be Webb's first start this season with his team as the moneyline favorite. Last season in games Marquez pitched his team went 8-18-0 against the spread. Marquez and his team finished 6-18 in the 24 games he appeared in when they were the moneyline underdog a season ago.

Giants vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (53.3%)

Giants vs Padres Moneyline

• The moneyline numbers for Giants vs. Padres reveal San Francisco as the favorite (-144) and San Diego as the underdog (+122) despite being the home team.

Giants vs Padres Spread

• The Giants are at the Padres and are favored by 1.5 runs (+122 to cover) on the runline. San Diego is -146 to cover.

Giants vs Padres Over/Under

• The over/under for the Giants versus Padres game on March 31 has been set at 7.5, with -118 odds on the over and -104 odds on the under.

Bet on San Francisco Giants vs. San Diego Padres on FanDuel today!

Giants vs Padres Betting Trends

• The Giants were favorites in 94 games last season and came away with the win 50 times (53.2%) in those contests.
• Last season San Francisco came away with a win 30 times in 52 chances when named as a favorite of at least -144 or shorter on the moneyline.
• The Giants and their opponents hit the over in 77 of their 161 games with a total last season.
• The Padres compiled a 34-36 record in games last season when they were listed as the moneyline underdog (winning 48.6% of those games).
• In games it played as a moneyline underdog with odds of +122 or longer last year, San Diego went 12-16 (42.9%).
• The Padres played in 163 games with an over/under set last season, and combined with their opponents to go over the total 70 times (70-90-3).

Giants Player Leaders

• Rafael Devers had 153 hits and an OBP of .372 last season.
• Luis Arraez hit eight homers while driving in 61 runs.
• Last season, Willy Adames finished with 30 home runs, 87 RBI and a batting average of .225 last season.
• Jung Hoo Lee slashed .266/.327/.407 and finished with an OPS of .735.

Padres Player Leaders

• Fernando Tatis Jr. had a .368 on-base percentage while batting .268 last season.
• Manny Machado racked up 169 hits and slugged .460.
• Ramon Laureano had 26 doubles, two triples, 24 home runs and 35 walks while batting .281 last season.
• Xander Bogaerts hit .263 with 30 doubles, 11 home runs and 48 walks.

Giants vs Padres Head to Head

• 3/30/2026: 3-2 SF (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 8/21/2025: 8-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 8/20/2025: 8-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/19/2025: 5-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 8/18/2025: 4-3 SF (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/13/2025: 11-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 8/12/2025: 5-1 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/11/2025: 4-1 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/5/2025: 3-2 SF (Favorite: Giants, Spread: -1.5, Total: 7, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/4/2025: 6-5 SF (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: -102)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!