Cubs vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for April 3

Odds updated as of 5:13 a.m.

The Chicago Cubs versus the Cleveland Guardians is on the MLB schedule for Friday.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Cubs vs Guardians Game Info

• Chicago Cubs (3-3) vs. Cleveland Guardians (4-3)
• Date: Friday, April 3, 2026
• Time: 4:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and MARQ

Cubs vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-118) | CLE: (+100)
• Spread: CHC: -1.5 (+155) | CLE: +1.5 (-188)
• Total: 7.5 -- Over: (-105) | Under: (-115)

Cubs vs Guardians Probable Starting Pitchers

Probable Pitchers: Cade Horton (Cubs) - 1-0, 2.84 ERA vs Joey Cantillo (Guardians) - 0-0, 4.91 ERA

The Cubs will give the nod to Cade Horton (1-0) versus the Guardians and Joey Cantillo. Horton helped his team cover the spread in his only opportunity this season as a starter. Horton's team won his only start as a favorite this season. Cantillo has started only one game with a set spread, which the Guardians covered. The Guardians were the moneyline underdog for one Cantillo start this season -- they won.

Cubs vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (56.9%)

Cubs vs Guardians Moneyline

• The Cubs vs Guardians moneyline has Chicago as a -118 favorite, while Cleveland is a +100 underdog at home.

Cubs vs Guardians Spread

• The Cubs are at the Guardians and are favored by 1.5 runs (+155 to cover) on the runline. Cleveland is -188 to cover.

Cubs vs Guardians Over/Under

• The over/under for Cubs-Guardians on April 3 is 7.5. The over is -105, and the under is -115.

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Cubs vs Guardians Betting Trends

• The Cubs have come away with three wins in the six contests they have been listed as the favorites in this season.
• This season Chicago has come away with a win three times in six chances when named as a favorite of at least -118 on the moneyline.
• The Cubs' games have gone over the total in three of their six opportunities.
• The Cubs have posted a record of 3-3-0 against the spread this season.
• The Guardians have gone 4-3 in games they were the underdog on the moneyline (winning 57.1% of those games).
• When it has played as a moneyline underdog with odds of +100 or longer, Cleveland has a record of 4-3 (57.1%).
• The Guardians have had an over/under set by bookmakers seven times, and have combined with opponents to go over the total in three of those games (3-4-0).
• The Guardians have covered 57.1% of their games this season, going 4-3-0 against the spread.

Cubs Player Leaders

• Nico Hoerner has an OPS of .885, fueled by an OBP of .385 and a team-best slugging percentage of .500 this season. He has a .318 batting average.
• Among all qualifying hitters, he is 44th in batting average, his on-base percentage ranks 54th, and he is 52nd in slugging.
• Hoerner hopes to build on a five-game hitting streak in this matchup. During his last five outings he is hitting .389 with four doubles, three walks and three RBIs.
• Ian Happ has five hits, which leads Chicago batters this season. He's batting .208 with four extra-base hits. He's also slugging .625 with an on-base percentage of .321.
• Among all qualifying players, he is 114th in batting average, 100th in on-base percentage and 24th in slugging percentage.
• Alex Bregman is batting .208 with a .458 slugging percentage and three RBI this year.
• Michael Busch leads Chicago with an OBP of .423 this season while batting .286 with five walks and five runs scored.

Guardians Player Leaders

• Chase DeLauter paces the Guardians with six hits. He's batting .273 and slugging .818 with an on-base percentage of .304.
• He ranks 66th in batting average, 112th in on-base percentage and eighth in slugging percentage among all qualifying hitters in MLB.
• Jose Ramirez is batting .143 with two doubles, a home run and two walks. He's slugging .321 with an on-base percentage of .200.
• He is currently 171st in batting average, 173rd in on-base percentage and 112th in slugging percentage among all qualifying batters.
• Steven Kwan has a .296 slugging percentage, which paces the Guardians.
• Brayan Rocchio's .360 on-base percentage leads his team.

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