Cardinals vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for April 8

Odds updated as of 10:12 p.m.

The St. Louis Cardinals will take on the Washington Nationals in MLB action on Wednesday.

All the info you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cardinals vs Nationals Game Info

• St. Louis Cardinals (5-5) vs. Washington Nationals (4-6)
• Date: Wednesday, April 8, 2026
• Time: 4:05 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: Nationals.TV and Cardinals.TV

Cardinals vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-132) | WSH: (+112)
• Spread: STL: -1.5 (+134) | WSH: +1.5 (-162)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Cardinals vs Nationals Probable Starting Pitchers

Probable Pitchers: Michael McGreevy (Cardinals) - 0-1, 2.53 ERA vs Miles Mikolas (Nationals) - 0-2, 14.46 ERA

The probable starters are Michael McGreevy (0-1) for the Cardinals and Miles Mikolas (0-2) for the Nationals. McGreevy has a record of 1-1-0 ATS in two starts with a spread this season. This will be McGreevy's first game as the moneyline favorite this season. Mikolas has started two games with set spreads, and the Nationals failed to cover in both opportunities. The Nationals were named the moneyline underdog for two Mikolas starts this season -- they lost both.

Cardinals vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (52%)

Cardinals vs Nationals Moneyline

• Washington is the underdog, +112 on the moneyline, while St. Louis is a -132 favorite despite being on the road.

Cardinals vs Nationals Spread

• The Cardinals are 1.5-run road favorites on the runline against the Nationals. The Cardinals are +134 to cover, and the Nationals are -162.

Cardinals vs Nationals Over/Under

• The over/under for the Cardinals versus Nationals game on April 8 has been set at 8.5, with -105 odds on the over and -115 odds on the under.

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Cardinals vs Nationals Betting Trends

• The Cardinals were defeated in the one game they played as the favorite this season.
• St. Louis has not played a game this season with better moneyline odds than -132.
• The Cardinals' games have gone over the total in five of their 10 opportunities.
• The Cardinals are 5-5-0 against the spread in their 10 games with a line set by sportsbooks this season.
• The Nationals have been the moneyline underdog 10 total times this season. They've finished 4-6 in those games.
• Washington is 3-6 (winning just 33.3% of its games) when playing as a moneyline underdog of +112 or longer.
• The Nationals have combined with opponents to go over the total eight times this season for an 8-2-0 record against the over/under.
• The Nationals have collected a 6-4-0 record ATS this season.

Cardinals Player Leaders

• Jordan Walker leads St. Louis with 11 hits and a team-best slugging percentage of .629. He's batting .314 with an on-base percentage of .385.
• He ranks 28th in batting average, 45th in on-base percentage, and 11th in slugging among qualified hitters in baseball.
• Walker hopes to build on a three-game hitting streak in this matchup. During his last five outings he is batting .333 with two home runs, a walk and six RBIs.
• Alec Burleson has two doubles, a home run and seven walks. He's batting .216 and slugging .351 with an on-base percentage of .333.
• He ranks 114th in batting average, 81st in on-base percentage and 111th in slugging among qualifying hitters.
• JJ Wetherholt leads St. Louis in OBP (.386) this season, fueled by 10 hits.
• Wetherholt has recorded at least one base hit in three straight games. During his last five outings he is batting .250 with four walks.
• Ivan Herrera has no home runs, but six RBI and a batting average of .200 this season.

Nationals Player Leaders

• C.J. Abrams paces the Nationals with 10 hits. He's batting .286 and slugging .629 with an on-base percentage of .390.
• He ranks 46th in batting average, 36th in on-base percentage and 11th in slugging percentage among all qualified batters in the big leagues.
• Abrams hopes to build on a seven-game hitting streak in this matchup. In his last nine outings he is batting .286 with four home runs, five walks and 13 RBIs.
• Joey Wiemer has a triple, two home runs and five walks while hitting .476. He's slugging .857 with an on-base percentage of .577.
• Luis Garcia is hitting .306 with three doubles, a triple, a home run and a walk.
• James Wood is hitting .163 with three doubles, three home runs and seven walks.

Cardinals vs Nationals Head to Head

• 4/6/2026: 9-6 WSH (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/10/2025: 8-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/9/2025: 8-2 WSH (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/11/2025: 6-1 STL (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/10/2025: 4-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/9/2025: 10-0 STL (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 7/28/2024: 4-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 7/27/2024: 14-3 WSH (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 7/26/2024: 10-8 WSH (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 7/8/2024: 6-0 STL (Favorite: Nationals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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