Cardinals vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for April 6

Odds updated as of 2:12 a.m.

The St. Louis Cardinals versus the Washington Nationals is on the MLB schedule for Monday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding this game.

Cardinals vs Nationals Game Info

• St. Louis Cardinals (5-4) vs. Washington Nationals (3-6)
• Date: Monday, April 6, 2026
• Time: 6:45 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: Nationals.TV and Cardinals.TV

Cardinals vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-110) | WSH: (-106)
• Spread: STL: -1.5 (+155) | WSH: +1.5 (-188)
• Total: 8 -- Over: (-122) | Under: (+100)

Cardinals vs Nationals Probable Starting Pitchers

Probable Pitchers: Andre Pallante (Cardinals) - 1-0, 0.00 ERA vs Zack Littell (Nationals) - 0-1, 5.40 ERA

The Cardinals will give the nod to Andre Pallante (1-0, 0.00 ERA), who is eyeing win No. 2 on the season, and the Nationals will turn to Zack Littell (0-1, 5.40 ERA). Pallante helped his team cover the spread in his only opportunity this season as a starter. This will be Pallante's first start this season with his team as the moneyline favorite. Last season when Littell pitched his team went 18-15-0 against the spread. Littell and his team finished 11-11 in the 22 games he pitched when they were the underdog on the moneyline a season ago.

Cardinals vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (52.6%)

Cardinals vs Nationals Moneyline

• The moneyline numbers for Cardinals vs. Nationals reveal St. Louis as the favorite (-110) and Washington as the underdog (-106) despite being the home team.

Cardinals vs Nationals Spread

• The Cardinals are at the Nationals and are favored by 1.5 runs (+155 to cover) on the runline. Washington is -188 to cover.

Cardinals vs Nationals Over/Under

• An over/under of 8 has been set for Cardinals-Nationals on April 6, with the over being -122 and the under +100.

Bet on St. Louis Cardinals vs. Washington Nationals on FanDuel today!

Cardinals vs Nationals Betting Trends

• The Cardinals will be named as the favorite for the first time this season.
• Oddsmakers have given St. Louis the best odds of winning it has seen this season, with a -110 moneyline listed for this contest.
• The Cardinals and their opponents have hit the over in four of their nine games with a total set by oddsmakers this season.
• In nine games with a line this season, the Cardinals have a mark of 5-4-0 against the spread.
• The Nationals have won 33.3% of the games this season they were the moneyline underdog (3-6).
• Washington has gone 3-6 in games it has played as a moneyline underdog with odds of -106 or longer (33.3%).
• The Nationals have played in nine games with a set over/under, and have combined with their opponents to go over the total seven times (7-2-0).
• The Nationals have put together a 5-4-0 record ATS this season (covering 55.6% of the time).

Cardinals Player Leaders

• Jordan Walker leads St. Louis with nine hits and an OBP of .382, plus a team-best slugging percentage of .567. He's batting .300.
• Among qualifying batters in MLB, he ranks 39th in batting average, 41st in on-base percentage, and 27th in slugging.
• Walker has picked up at least one hit in two straight games. During his last five outings he is hitting .235 with a home run, a walk and five RBIs.
• Alec Burleson is hitting .242 with two doubles, a home run and six walks, while slugging .394 with an on-base percentage of .350.
• Among qualifying batters, he ranks 84th in batting average, 70th in on-base percentage and 87th in slugging percentage.
• JJ Wetherholt has an OPS of .723, fueled by an OBP of .359 and a team-best slugging percentage of .364 this season.
• Wetherholt enters this game with two games in a row with at least one hit. In his last five games he is hitting .294 with two walks.
• Ivan Herrera is batting .226 with a .375 OBP and six RBI for St. Louis this season.
• Herrera has safely hit in six games in a row. In his last nine games he is batting .226 with three doubles, seven walks and six RBIs.

Nationals Player Leaders

• C.J. Abrams has put up an on-base percentage of .389 and has nine hits, both team-high numbers for the Nationals. He's batting .290 and slugging .581.
• Including all qualified hitters, he is 47th in batting average, while his on-base percentage is 36th and he is 22nd in slugging.
• Abrams heads into this game on a six-game hitting streak. During his last eight outings he is hitting .290 with three home runs, four walks and 12 RBIs.
• Joey Wiemer is batting .476 with a triple, two home runs and five walks. He's slugging .857 with an on-base percentage of .577.
• Luis Garcia is hitting .324 with three doubles, a triple and a home run.
• Daylen Lile's .375 slugging percentage leads his team.

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