USC vs UCLA Prediction, Odds & Best Bet for Week 12 (UCLA Upsets in Battle for Victory Bell)

USC vs UCLA Week 12 Game Info

2022 NCAA College Football Game
No. 7 USC Trojans (9-1, 7-1 Pac 12) vs. No. 16 UCLA Bruins (8-2, 5-2 Pac 12)
Date: Saturday, Nov. 19, 2022
Time: 8 p.m. ET
Venue: Rose Bowl Stadium — Los Angeles, CA
Coverage: FOX

Week 12 of the 2022 NCAA college football season includes Pac 12 crosstown rivalry between No. 7 USC Trojans and No. 16 UCLA Bruins, who play their last home game with an longshot chance to make the Pac 12 championship game in a complicated tie-breaker. The Bruins had a major setback last week losing as a 20-point favorite to Arizona, 34-28.

Meanwhile, Southern Cal controls their destiny to the Pac 12 championship. A win over their rival UCLA and the Trojans finish 8-1 in the conference and move to the Pac 12 Championship Game and keep their College Football Playoff hopes alive.

USC vs UCLA Odds & Spread

All NCAAF betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: USC: (-132) | UCLA: (+110)
Spread: USC: -2.5 (-110) | UCLA: +2.5 (-110)
Total: 75.5 — Over: (-114) | Under: (-106)

USC enters this contest as a slight road favorite on the spread (-2.5) and moneyline (-132). The takeback on a UCLA win is +110. The total has dropped sharply from Sunday's opener in Las Vegas of 82.5, and now sits at 75.5 points - nearly 20 points higher than an average college football over/under on this week's games.

USC vs UCLA Prediction & Pick

Both USC and UCLA has similar offensive profiles scoring 39-42 points per game (PPG) and averaging 500-506 yards per game (YPG) - both top 10 in the country. The defensive profiles are similar as well allowing 25-28 PPG and 386-394 YPG vs FBS opponents.

UCLA blew out USC last year as a small road dog. Quarterback Thompson-Robinson and Zach Charbonnet keyed the blowout victory last season. Thompson-Robinson passed for 349 yards and had 6 total TDs, and Charbonnet had 167 yards and a TD. The Trojans have a new defensive scheme, but Charbonnet is still rolling leading the Pac 12 in rushing 1,145 yards (143/game) and TD's (13). UCLA is No. 3 in the nation among Power 5 teams in rushing averaging 242 YPG including a nation-high 6.3 yards per rush with duel-threat Thompson-Robinson adding rushing 7 touchdowns to his 71% completion rate and 20 TD passes.

USC is now without leading rusher Travis Dye, who suffered a season-ending leg injury vs Colorado Nov. 11. Trojans QB Caleb Williams will try to carry the offense again with leading receiver Jordan Addison WR Mario Williams potentially returning after essentially being out since the Utah game. Williams has passed for 31 TD's this season and at least 360 yards in three of the last four games including at Utah with 5 TD's in the Trojans only loss this season, 43-42.

Final Score Prediction: UCLA: 37 | USC: 31

USC vs UCLA Betting Trends

- USC is 9-1 straight up (SU) in their last 10 games.
- USC is 5-2 SU in their last 7 games vs UCLA
- USC is 2-5 against the spread (ATS) in their last 7 road games.
- The total has gone Over in 5 of USC's last 6 games.
- UCLA is 11-2 SU in their last 13 games.
- UCLA is 5-2 ATS in their last 7 games.
- The total has gone Over in 4 of the last 5 UCS vs UCLA games.

USC vs UCLA Best Bet

All NCAAF betting lines, odds and prop bets are available on FanDuel Sportsbook.

The line has dipped below the key number 3 from the opener, and the total has dropped down significantly as well but would still lean 'under'. First-year USC coach Lincoln Riley is 6-14 ATS in his career as road favorite, but also 22-2 in November/December in the regular season and conference championship games coaching at Oklahoma and USC. He's guided the Trojans to 9 wins after USC went 4-8 last season. One of those losses was an ugly one to UCLA 62-33.

USC lost at Utah 43-42 when fully healthy, and escaped at Oregon State 17-14 in their two toughest games. The Trojans have taken advantage of a nation-best +17 turnover margin with USC defensive dominator DE Tuli Tuipulotu registering 11.5 sacks and 17.5 tackles for loss. But UCLA edge rusher Laiatu Latu is also an All-American candidate with 8 sacks and 9.5 tackles for loss. UCLA coach Chip Kelly has an experience edge for this big rivalry, and quality players to win again and end USC's hopes of a Pac 12 title and any CFB Playoff aspirations.

Bet: UCLA +2.5 (-106) and Moneyline +110

Game odds refresh periodically and are subject to change.