USC vs Oregon State Prediction, Odds & Betting Trends for College Football Week 4 Game on FanDuel Sportsbook

Updated: Sep 10, 5:00pm UTC

USC vs Oregon State Week 4 Game Info

2022 NCAA College Football Game
USC Trojans (3-0, 1-0 Pac 12) vs. Oregon State Beavers (3-0, 0-0 Pac 12)
Date: Saturday, Sept. 24, 2022
Time: 9:30 p.m. ET
Venue: Reser Stadium — Corvallis, OR
Coverage: Pac 12 Network

Week 4 of the 2022 NCAA college football season includes a Pac 12 showcase between the No. 7 USC Trojans and Oregon State Beavers. Southern Cal has scored 152 points in three games and shot up the AP Pool to No. 7 this week.

It's the conference opener for Oregon State while USC has a 41-28 Week 2 win over Stanford after building 28-7 and 41-14 leads.

USC vs Oregon State Odds & Spread

All NCAAF betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: USC: (-230) | OSU: (+188)
Spread: USC: -5.5 (-114) | OSU: +5.5 (-106)
Total: 70.5 — Over: (-110) | Under: (-110)

USC enters this contest as the road favorite, but the line on the No. 7 Trojans has fallen a point to -5.5 with the moneyline now -230 and nearly a 2/1 takeback on the underdog Beavers (+188). This Saturday night kickoff also features the highest total of the week with a posted over/under of 70.5 points.

USC vs Oregon State Prediction & Pick

The USC defense showed more life in the second half last week notching four sacks to aid the offense in pulling away for a 45-17 home win over Fresno State. The Trojans offense continues to roll with 29 first downs and a strong, balanced attack last week with 233 rushing and 284 passing yards. Quarterback Caleb Williams is now a top Heisman contender with +300 odds. He passed for 341 yards and 4 TDs on just 27 attempts versus Stanford, and the sophomore slinger is averaging 291 passing yards per game with an 8-to-0 TD-INT ratio.

Last season, Oregon State earned a 45-27 road win over USC as a double-digit underdog. The Beavers rushed for a season-high 322 yards, and OSU running backs Deshaun Fenwick and standout freshman Damien Martinez have shown flashes through three games as the Beavers have 11 rushing touchdowns, the most in the Pac-12. Beavers junior QB Chance Nolan has been consistent and efficient while averaging just shy of 10 yards per pass attempt.

Final Score Prediction: USC: 34 | Oregon State: 31

USC vs Oregon State Betting Trends

USC is 4-1 against the spread (ATS) in their last 5 games.
USC is 4-1 straight up (SU) in their last 5 games vs Oregon State.
Oregon State is 5-2 SU and ATS in their last 7 games.
Oregon State is 7-0 ATS in their last 7 home games.
The total has gone Under in 5 of Oregon State's last 6 games against Southern California.

USC vs Oregon State Best Bet

All NCAAF betting lines, odds and prop bets are available on FanDuel Sportsbook.

The Trojans offense is explosive, but the defense can be had against the run with USC allowing 177 rushing yards per game. The Trojans lead the nation with a +10 turnover differential which has added to their domination thus far.

Tougher to bet against the explosive Trojans offense averaging 520 yards per game and covering all three games this season by an average of 13 points per game. But the Beavers are also 3-0 ATS covering by 14 PPG and a common opponent win over Fresno State, 35-32 on the road.

Oregon State has covered their last 7 home games and lean their way as home 'Dog.