Steelers vs Bills Opening Odds, Betting Lines & Prediction for Week 5 Game on FanDuel Sportsbook

Week 4 NFL action is underway, but FanDuel Sportsbook has already released NFL odds and lines for Week 5, giving us an early preview of next week's slate.

Week 5's 1 p.m. slate sets up an exciting matchup between the Pittsburgh Steelers and Buffalo Bills.

Steelers vs Bills Odds & Lines Week 5

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: PIT: (+520) | BUF: (-720)
Spread: PIT: +12.5 (-110) | BUF: -12.5 (-110)
Total: N/A — Over: (N/A) | Under: (N/A)

The Bills return home as a massive favorite against the Steelers in Week 5. Buffalo is an early -720 moneyline favorite and is favored by 12.5 point on the spread.

Steelers vs Bills Prediction Week 5

Early NFL predictions and picks are from ESPN's Football Power Index (FPI).
Steelers: 15.9% to win
Bills: 84.0% to win

This contest could end up as a blowout, according to the opening betting lines. ESPN's FPI seems to also think the Bills get the job done here and I agree. Buffalo rosters pass-catchers that can frustrate Pittsburgh by racking up yards after the catch and possesses a defense capable of keeping quarterback Mitchell Trubisky or Kenny Pickett uncomfortable in the pocket. The Bills will have another week to get healthy in the secondary, so seeing them win by two touchdowns wouldn't be surprising. Bet Bills -12.5 (-110).

Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.