Penn State vs Purdue Prediction, Odds & Betting Trends for College Football Game on FanDuel Sportsbook

Penn State vs Purdue Week 1 Game Info

2022 NCAA College Football Game
Penn State Nittany Lions (0-0) vs. Purdue Boilermakers (0-0)
Date: Thursday, September 1, 2022
Time: 8:00 p.m. ET
Venue: Ross-Ade Stadium — West Lafayette, IN
Coverage: FOX

Week 1 of the 2022 NCAA college football season includes a Big Ten showdown between the Penn State Nittany Lions and Purdue Boilermakers. Penn State is back for another year under James Franklin and will lean on veteran quarterback Sean Clifford to lead a fresh set of faces on offense.

Meanwhile, Purdue will be aiming to keep their momentum going from a 10-win 2021 season that ended with a Music City Bowl win over Tennessee. Aidan O'Connell returns for another year at QB, but he will have some new weapons to throw to following wide receiver David Bell's departure to the NFL.

Penn State vs Purdue Odds & Spread

All NCAAF betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: PSU: (-178) | PUR: (+146)
Spread: PSU: -3.5 (-104) | PUR: +3.5 (-118)
Total: 53.5 — Over: (-105) | Under: (-115)

Penn State enters this contest as the small favorite on the moneyline and the spread. This 8 p.m. ET clash also features a total of 53.5, which is about average compared to this week's college football projected totals.

Penn State vs Purdue Prediction & Pick

It's hard to overlook how dominant Penn State has been in this head-to-head series. The Nittany Lions are 15-3-1 against the Boilermakers and currently riding a nine-game winning streak. Most recently, Clifford threw for 264 yards and 3 touchdowns against Purdue in a 35-7 win in 2019.

Franklin's team has a lot to prove here, too. The Nittany Lions enter the season unranked for the first time since 2016 and stuck behind Big Ten powerhouses like Ohio State and Michigan in media coverage. Look for Penn State to come out firing and build enough of an early lead to win.

Final Score Prediction: Penn State: 31 | Purdue: 21

Penn State vs Purdue Betting Trends

- Penn State is 9-0 straight up in its last nine games against Purdue.
- The total has hit the under in 12 of Penn state's last 15 away games.
- Purdue is 3-6 against the spread (ATS) in its last nine home games.
- The total has hit the under in nine of Purdue's last 12 games against Penn State.

Penn State vs Purdue Best Bet

All NCAAF betting lines, odds and prop bets are available on FanDuel Sportsbook.

In its last 15 games against Purdue, Penn State is an impressive 10-4-1 against the spread (ATS). Not only that, but the Boilermakers have posted a 3-6 record ATS in its last nine home games. Neither one of those facts should make bettors thinking of backing Purdue confident the team will cover.

The Nittany Lions are 7-0 straight up in their last seven games played in September. They know how to come out the gates hot and Clifford's experience running this offense is a major advantage for Penn State. That familiarity will result in efficient drives down the field, so back PSU on the spread.

Bet: Penn State -3.5 (-104)

Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.