NC State vs Louisville Prediction, Odds & Best Bet for Week 12 (Both Teams Struggle to Find the End Zone)

NC State vs Louisville Week 12 Game Info

2022 NCAA College Football Game
No. 24 NC State Wolfpack (7-3, 3-3 ACC) vs. Louisville Cardinals (6-4, 3-4 ACC)
Date: Saturday, Nov. 19, 2022
Time: 3:30 p.m. ET
Venue: Cardinal Stadium — Louisville, KY
Coverage: ESPN3

Week 12 of the 2022 college football season includes an ACC showdown between the No. 24 NC State Wolfpack and Louisville Cardinals. NC State dropped a tough game to Boston College in Week 11 by a final score of 21-20. Quarterback MJ Morris racked up 157 total yards and 2 touchdowns.

Meanwhile, Louisville fell short against Clemson in a 31-16 loss on Saturday. Starting quarterback Malik Cunningham was forced to leave the game early due to a shoulder injury. Brock Domann stepped in to complete 13 of his 23 pass attempts for 175 yards, 1 touchdown and 1 interception.

NC State vs Louisville Odds & Spread

All NCAAF betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: NCSU: (+155) | LOUIS: (-188)
Spread: NCSU: +3.5 (-112) | LOUIS: -3.5 (-108)
Total: 44.5 — Over: (-104) | Under: (-118)

Louisville enters this contest as a small home favorite on the moneyline and the spread. This ACC clash also features a total of 44.5 points, which is below average compared to this week's college football projected totals.

NC State vs Louisville Prediction & Pick

This is a tough game to predict as Cunningham is considered "day-to-day" by the Louisville coaching staff. The senior QB is the heartbeat of the Cardinals' offense, averaging over 172 passing yards and 61 rushing yards per game. He has also accounted for 19 of the team's 32 offensive TDs this season.

I'm going to give the edge to NC State because of its stellar rush defense. The Wolfpack are allowing just 98.6 rushing yards per game on 3.5 yards per carry. Both of those averages check in as a top-20 mark in the country. Winning this game on the ground will be nearly impossible for the Cardinals.

Keep in mind NC State walloped Louisville by a score of 52-10 the last time it came to town in 2019.

Final Score Prediction: NC State: 21 | Louisville: 17

NC State vs Louisville Betting Trends

- NC State is 1-6 against the spread (ATS) in its last seven games.
- The total has hit the under in four of NC State's last six games against Louisville.
- Louisville is 5-2 ATS in its last seven home games.
- The total has hit the over in four of Louisville's last six games against an ACC opponent.

NC State vs Louisville Best Bet

While the Cardinals may be without their top QB for the first time this season, NC State has been without Devin Leary for weeks now. It has caused the offense to become hit or miss on any given week. The Wolfpack are averaging a disappointing 16.7 points per game when away from home.

The total has hit the under in four of the last six head-to-head matchups between NC State and Louisville. It has also hit the under in four of the Cardinal's last six Week 12 contests. Neither team is at full strength on offense, so expect to see a ton of stalled drives and punts on Saturday afternoon.

Bet: Under 44.5 Points (-118)

Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.