NC State vs Clemson Prediction, Odds & Betting Trends for College Football Game on FanDuel Sportsbook

Updated: Sep 10, 5:00pm UTC

NC State vs Clemson Week 5 Game Info

2022 NCAA College Football Game
No. 5 Clemson Tigers (4-0, 2-0 ACC) vs. No. 10 NC State Wolfpack (4-0, 0-0 ACC)
Date: Saturday, Oc. 1, 2022
Time: 7:30 p.m. ET
Venue: Memorial Stadium — Clemson, SC
Coverage: ABC

Week 5 of the 2022 NCAA college football season features a prime time Saturday night ACC showdown between No. 5 Clemson Tigers and No. 10 NC State Wolfpack.

These are two of the four undefeated teams in the tougher Atlantic division, but the ACC is moving away from the split divisions next season.

NS State vs Clemson Odds & Spread

All NCAAF betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: NCST: (+215) | CLEM: (-265)
Spread: NCST: +7 (-112) | CLEM: -7 (-108)
Total: 43.5 — Over: (-108) | Under: (-112)

Clemson is a -7 favorite on the spread and -265 moneyline with the takeback on NC State +215 for the Wolfpack to win the game outright. The total has dipped down to 43.5.

NC State vs Clemson Prediction & Pick

What a wild game last week in Clemson's 51-45 double-overtime win over Wake Forest. That kept the Tigers on top of the Atlantic division with NC State, Florida State and Syracuse. But only NC State has yet to play a conference game.

Last season, unranked NC State upset Clemson 27-21 in double-overtime as a 10-point home underdog. Now the Wolfpack are even better with QB Devin Leary passing for nearly 900 yards and 9 TDs after last year's 3,433 yards and 35 touchdowns led NC State to a special season.

The Wolfpack defense has allowed just 47 points in four games - lowest in the ACC - and the reason why this total is so low despite Clemson's 51 points scored last week. NC State has rolled over three weaker opponents since a Week 1 scare against East Carolina.

Clemson has won 36 straight home games, including five against ranked opponents. But the Tigers are on upset alert as the Wolfpack can win this game with a strong defense and top-rated back seven. Add in a top ACC quarterback in Devin Leary, who is polished, efficient and accurate with a quick release, and you have a potential upset Saturday at Memorial Stadium.

Final Score Prediction: NC State: 27 | Clemson: 24

NC State vs Clemson Betting Trends

- NC State is 6-0 straight up (SU) in their last 6 games.
- NC State is 1-8 SU in their last 9 games at Clemson
- The total has hit the Over in 5 of NC State's last 7 games.
- Clemson is 10-0 SU in their last 10 games, and 20-0 in their last 20 home games.
- Clemson is 6-12 against the spread (ATS) in their last 18 games.
- The total has gone Under in 4 of Clemson's last 6 games.

NC State vs Clemson Best Bet

All NCAAF betting lines, odds and prop bets are available on FanDuel Sportsbook.

Rain is in the forecast in Death Valley, so monitor along with the betting lines. NC State is veteran team with a top quarterback and defense. The Wolfpack are also much healthier than the banged up Tigers, who do feature a defensive front with future pros. Tigers QB D.J. Uiagalelei has passed for more than 1,000 yards with 10 TDs and just 1 interception. But recall he stunk in last year's game at NC State with less than 50% completions and just 111 passing yards.

The Clemson suspect secondary has also been getting torched, including last week's 337 yards and 6 TDs by Wake Forest QB Sam Hartman. Clemson allowed more than 300 passing yards to Louisiana Tech in a game the Tigers led just 13-6 at halftime before winning 48-20. Even an FCS quarterback at Furman competed 30-of-39 passes for 256 yards against Clemson.

Devin Leary passed for 4 TDs in last year's Wolfpack win over the Tigers, and NC State is the side to support again.