Florida State vs Louisville Prediction, Odds & Betting Trends for College Football Week 3 Game on FanDuel

Florida State vs Louisville Week 3 Game Info

2022 NCAA College Football Game
Florida State (2-0, 0-0 ACC) vs. Louisville Cardinals (1-1, 0-1 ACC)
Date: Friday, Sept. 16, 2022
Time: 7:30 p.m. ET
Venue:  Cardinal Stadium -- Louisville, KY
Coverage: ESPN

Week 3 of the 2022 NCAA college football season includes a Friday night feature on ESPN between ACC rivals Florida State Seminoles and Louisville Cardinals.

Louisville has won the last two meetings, but FSU won the prior two and this is the fifth straight year with a point spread less than 7 points between these two teams.

Florida State vs Louisville Odds & Spread

All NCAAF betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: FSU: (-140) | LOU: (+116)
Spread: FSU: -2.5 (-110) | LOU: +2.5 (-110)
Total: 54.5 — Over: (-112) | Under: (-108)

Florida State enters this contest as a -2.5 favorite and -140 on the moneyline. This 7:30 p.m. ET feature on ESPN has seen the total just below average at 54.5.

Florida State vs Louisville Prediction & Pick

Louisville pulled off the upset last Friday night at Central Florida 20-14 with a balanced offensive attack. Senior QB Malik Cunnningham passed for 195 yards and rushed for 121 of the Cardinals 226 rushing yards. Cunningham has yet to throw a touchdown pass in two games this season and has been intercepted twice while operating behind the ACC's top-rated offensive line, according to Phil Steele's preseason ratings.

Florida State had an early season bye last week which followed a big 24-23 win vs LSU in the crazy finish in New Orleans. Florida State has had extra prep time for duel QB Cunningham, and the Seminoles have an improved defense this season.

Final Score Prediction: Florida State: 27 | Louisville: 24

Florida State vs Louisville Betting Trends

• Florida State is 4-1 straight up (SU) and 4-1 against the spread (ATS) in their last 5 games.
• Florida State is 2-14 SU in their last 16 road games.
• The total has gone under in Florida State's last 6 games.
• Louisville is 12-6 SU in their last 18 home games.
• The total has gone Under is 5 of Louisville's last 7 games vs ACC opponents.

Florida State vs Louisville Best Bet

All NCAAF betting lines, odds and prop bets are available on FanDuel Sportsbook.

Last season Louisville QB Cunningham passed for 264 yards and 2 TDs and added 56 rushing yards and 2 TDs in the Cardinals 31-23 win at Florida State. Now the FSU defense has an extra week to prepare, the the Seminoles figure to run the ball more. In a projected toss up, the underdog may be of interest but the road favorite has the situational edge off a bye and the stronger defense.

Bet: Under 54.5 (-108)