Cardinals vs Seahawks Prediction, Odds & Best Bet for Week 6

Week 6 of the 2022 NFL season includes a few divisional matchups, including an NFC West tilt between the Arizona Cardinals and Seattle Seahawks. Both teams are looking for some positivity as the Cardinals haven't been able to start any sort of win streak yet while the Seahawks have lost three of their last four games.

Cardinals vs Seahawks Odds

According to FanDuel Sportsbook's NFL odds, the Cardinals are a slight -144 favorite on the moneyline (3-point spread) in a game with an over/under of 50.5.

What should NFL fans expect in this matchup, and where can bettors find value?

Cardinals vs Seahawks Prediction and Best Bet

The Cardinals offense has been one of the more disappointing stories of the season. The team was expected to have some struggles without top wideout DeAndre Hopkins, but the 18.3 points per game that they've averaged over the last three weeks (eighth-worst) is worse than expected.

Although the Seahawks are far from perfect, no other team has scored more than their 34.3 PPG clip since Week 3. Pete Carroll's squad has scored 80 points over the last two weeks alone, which is bad news for the Cardinals, who own a bottom-11 defense.

Still, it hasn't been all bad for the Cardinals. They are 2-0 on the road this season, which is on top of the fact that they've also won five of their last seven trips to Lumen Field. Without Russell Wilson to worry about anymore, finding a win should be easier for Arizona.

Besides, the Seahawks own the second-worst scoring defense this season. Cardinals QB Kyler Murray averaged 30.3 completions, 289.7 passing yards and exactly two touchdowns in his last three games against Seattle, so this could be the opportunity he needs to get his team back on track.

At the end of the day, both teams have struggled, but this is a must-win game for the Cardinals. I can see Arizona getting the job done on the road, so take the Cardinals at -3 on the spread, as well as the total hitting over 50.5 points due to a total lack of defense here.

Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.

Game odds refresh periodically and are subject to change.