Buccaneers vs 49ers Prediction, Odds & Best Bets for Week 14 (Tampa Bay's Defense Triumphs in Road Upset)

Buccaneers vs 49ers Week 14 Game Info

2022 NFL Regular Season — Week 14
Tampa Bay Buccaneers (6-6, 2-3 Away) vs. San Francisco 49ers (8-4, 5-1 Home)
Date: Sunday, Dec. 11, 2022
Time: 4:25 p.m. ET
Venue: Levi's Stadium — Santa Clara, CA
Coverage: FOX

The Tampa Bay Buccaneers will aim to snap the San Francisco 49ers' five-game winning streak when they visit Levi's Stadium in Week 14. The Buccaneers are coming off a lively 17-16 win over the New Orleans Saints in which quarterback Tom Brady threw a touchdown pass with just seconds remaining.

Meanwhile, the 49ers took down the Miami Dolphins, 33-17, in Week 13. Defensive end Nick Bosa shined in the victory with 3.0 sacks, while three San Francisco defenders nabbed interceptions. All-Pro running back Christian McCaffrey paced the offense with 146 total yards and 1 touchdown.

Buccaneers vs 49ers Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: TB: (+154) | SF: (-184)
Spread: TB: +3.5 (-118) | SF: -3.5 (-104)
Total: 37.5 — Over: (-105) | Under: (-115)

The 49ers enter this contest as small home favorites on the moneyline and spread on FanDuel Sportsbook's odds. This 4:25 p.m. ET clash also features one of the lower totals on the Week 14 slate at 37.5 points.

Buccaneers vs 49ers Prediction & Pick

These teams enter Sunday with very different QB situations. Tom Brady looked like his old self on Sunday, which gives Buccaneers fans hope for a playoff run. On the other side, Jimmy Garoppolo suffered a broken foot in Week 13 and the 49ers will now rely on rookie Brock Purdy moving forward.

The good news is that Purdy didn't seem nervous against Miami as he completed 25 of his 37 passes for 210 yards, 2 touchdowns and 1 interception. The bad news is that Tampa Bay has posted the eighth-best pass defense DVOA rating and only allows 195.3 passing yards per game (No. 7 in NFL).

A rookie QB is no match for defenders like Devin White and Lavonte David, so I'll back the Bucs.

Final Score Prediction: Buccaneers: 20 | 49ers: 17

Buccaneers vs 49ers Betting Trends

- Tampa Bay is 1-8-1 against the spread (ATS) in its last 10 games.
- The total has hit the under in each of Tampa Bay's last five away games.
- San Francisco is 9-1 straight up in its last 10 home games.
- The total has hit the under in 14 of San Francisco's last 20 games.

Buccaneers vs 49ers Best Bet

As long as this point total stays above the 37-point mark, I favor the under. After all, the under has cashed in seven of Tampa Bay's last eight games as well as in 14 of San Francisco's last 20 games. The total has also hit the under in 14 of the last 20 head-to-head matchups between these NFC foes.

Tampa Bay is averaging 18.1 points per game (No. 27 in NFL) and allowing only 18.3 points per game (No. 5 in NFL). San Francisco is giving up just 15.8 points per game (No. 1 in NFL) and must turn to a rookie to run its offense. All of this adds up to a game in which there will be more punts than scores.

Bet: Under 37.5 Points (-115)

Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.