Bills vs Lions Prediction, Odds & Best Bet for Week 12 Thanksgiving Game (Expect Holiday Shooutout in Detroit)

Bills vs Lions Week 12 Game Info

2022 NFL Regular Season Game
Buffalo Bills (7-3, 3-2 Away) vs. Detroit Lions (4-6, 2-3 Home)
Date: Thursday, Nov. 24, 2022
Time: 12:30 p.m. ET
Venue: Ford Field — Detroit, MI
Coverage: CBS

Week 12 of the 2022 NFL season includes a Thanksgiving showdown between the Buffalo Bills and Detroit Lions. After back-to-back losses, the Bills are back on track after a 32-23 statement win against the Cleveland Browns. Buffalo's backfield did the brunt of the hard work, combining for 171 rushing yards and a touchdown on 33 carries.

Meanwhile, the Lions have turned a corner lately, winning three straight games after a 1-6 start to the year. Sunday's 31-18 win against the New York Giants saw Detroit running back Jamaal Williams find the end zone three different times while also rushing for 64 yards on 17 carries.

Bills vs Lions Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: BUF: (-420) | DET: (+330)
Spread: BUF: -9.5 (-105) | DET: +9.5 (-115)
Total: 53.5 —Over: (-115) | Under: (-105)

The Bills enter this contest as heavy favorites on the moneyline and spread on FanDuel Sportsbook's updated odds. This Thanksgiving clash also features an over/under of 53.5, which is the highest of the Week 12 totals. 

Bills vs Lions Prediction & Pick

Though the Lions have won three in a row, they haven't exactly been beating Super Bowl contenders. Knocking off the Giants was solid, however, Detroit's other two wins during this run came against the Chicago Bears and Green Bay Packers, who have a combined record of 7-15 this season.

The Bills have had some hiccups, but they've also scored 30-plus points in back-to-back weeks. While the Lions' offense is capable of going toe-to-toe with most teams, their defense is still allowing a league-worst 28.2 PPG. That's the type of matchup that Buffalo's offensive weapons will abuse and exploit.

With the Bills poised to be Super Bowl contenders and the Lions having a lot to learn, I'm going with Buffalo on Thursday.

Final Score Prediction: Bills: 35 | Lions: 23

Bills vs Lions Betting Trends

- Buffalo is 5-1 straight up in its last six games against Detroit.
- Detroit is 13-6 against the spread (ATS) in its last 19 games.
- The total has hit the under in six of Buffalo's last eight games.
- The total has hit the over in nine of Detroit's last 12 games.

Bills vs Lions Best Bet

As good as the Bills are, covering the 9.5-point spread could be tough. They've only won one game since Week 6 by 10-plus points and are 0-5 against the spread (ATS) in their last five games against NFC North teams. Furthermore, the Lions have covered the spread in 13 of their last 19 outings and will be poised to keep things close in front of their home crowd.

In a game where there should be a ton of points, I'm going with the Lions on the spread.

Bet: Lions +9.5 (-115)

Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.

Game odds refresh periodically and are subject to change.