3 Best Prop Bets for Chargers vs Chiefs Thursday Night Football Week 2

The Week 2 of the 2022 NFL season kicks off on Thursday with a matchup between the Los Angeles Chargers and Kansas City Chiefs. This contest features a staggering total of 53.5 points, meaning fans should expect a lot of points on the board between the two offensive-driven AFC West rivals.

Thursday Night Football Prop Bets

Here are three of the best prop bets for the Chargers vs. Chiefs matchup, courtesy of NFL odds on FanDuel Sportsbook.

Chargers vs Chiefs TNF Prop Bets Tonight

1. Mike Williams - Receiving Yards: Over 69.5 (-110)

Mike Williams will see his workload increase now that fellow Chargers wide receiver Keenan Allen has been ruled out for Thursday's contest. Fortunately, Williams seems to excel when the latter is out of the lineup. In three career games played without Allen, Williams has racked up 223 receiving yards on 19 receptions, which equates to 74.3 yards per game. The veteran wideout has also surpassed 100 receiving yards in two of his last three meetings with the Chiefs. With recent history and Allen's absence playing in Williams' favor, hitting 70-plus yards shouldn't be an issue.

2. Clyde Edwards-Helaire - Rushing Yards: Under 44.5 Yards (-110)

Now in his third NFL season, Clyde Edwards-Helaire has rarely put up big rushing numbers. He's averaging only 56.8 rushing yards through 24 games and while that's more than his projected Week 2, I have my doubts about him hitting it tonight. For starters, Edwards-Helaire has finished with 38 or fewer rushing yards in two of three career games against the Chargers. Secondly, finishing with 45-plus rushing yards is something he's done once in his last four home games. The truth is that the Chiefs simply don't run the ball that often, highlighted by CEH's average of 7.6 carries in his last five games. After the Chargers held the Las Vegas Raiders to 64 rushing yards last week, take the under here.

3. Patrick Mahomes - Passing TDs: Over 2.5 (+114)

Even though the under is favored on this prop, don't underestimate Patrick Mahomes. Even though the Chiefs QB is only averaging 2.3 touchdown passes in seven games against the Chargers, he's recorded a trio in each of the last two showdowns. It's also important not to forget that Mahomes just issued five TDs passes last week, so he's already in mid-season form. Even though Los Angeles' defense is tough, the secondary might be without top cornerback J.C. Jackson, who'll be a game-time decision. Even if Jackson does play, he likely won't be 100% due to his injured ankle. Throw in the game's high projected total and it's easy to see why Mahomes could realistically finish with at least three TD passes.

Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.