49ers vs Seahawks Opening Odds, Betting Lines & Prediction for Week 15 (Niners' Defense Powers Another Win)

Updated: Sep 10, 5:00pm UTC

Week 14 NFL action is underway, but FanDuel Sportsbook has already released NFL odds and lines for Week 15, giving us an early preview of the upcoming slate.

Week 15 includes a Thursday night clash between the San Francisco 49ers and Seattle Seahawks.

49ers vs Seahawks Odds & Lines Week 15

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: SF: (-120) | SEA: (+102)
Spread: SF: -1.5 (-110) | SEA: +1.5 (-110)
Total: N/A — Over: (N/A) | Under: (N/A)

The opening odds list the 49ers as slight road favorites in Week 15. San Francisco is -120 on the monyeline and favored by 1.5 points on the spread.

49ers vs Seahawks Prediction Week 15

Early NFL predictions and picks are from ESPN's Football Power Index (FPI).
49ers: 47.3% to win
Seahawks: 52.1% to win

This NFC West matchup should be a battle. Both offenses are full of playmakers, which could make this a potential shootout. However, San Francisco's defense should help lead this team to another win, even with Brock Purdy under center.

The 49ers rank No. 1 in fewest points and yards allowed, so they have the personnel to quiet the likes of Geno Smith and D.K. Metcalf. Seattle, meanwhile, ranks bottom five in both categories. All San Francisco needs is a fine showing from Purdy, and I think he's capable of producing against this vulnerable Seahawks unit. Bet 49ers -1.5 (-110).

Isaiah De Los Santos is not a FanDuel employee. In addition to providing DFS gameplay advice, Isaiah De Los Santos also participates in DFS contests on FanDuel using his personal account, username zayyy05328. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.

Game odds refresh periodically and are subject to change.