49ers vs Cardinals Prediction, Odds & Best Bets for Monday Night Football (San Francisco Dazzles in Mexico City)

49ers vs Cardinals Week 11 Game Info

2022 NFL Regular Season — Week 11
San Francisco 49ers (5-4) vs. Arizona Cardinals (4-6)
Date: Monday, Nov. 21, 2022
Time: 8:15 p.m. ET
Venue: Estadio Azteca — Mexico City
Coverage: ESPN

NFC West rivals meet head-to-head in Mexico City during Week 11 as the San Francisco 49ers face the Arizona Cardinals on Monday night. San Francisco is fresh off a 22-16 win over the Los Angeles Chargers in Week 10. Running back Christian McCaffrey scored his third touchdown as a 49er.

Meanwhile, the Cardinals took down the Los Angeles Rams by a score of 27-17 on Sunday. With quarterback Kyler Murray injured, Colt McCoy stepped up with 238 passing yards and 1 touchdown. Running back James Conner scored 2 touchdowns and safety Budda Baker nabbed an interception.

49ers vs Cardinals Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: SF: (-360) | ARI: (+290)
Spread: SF: -8.5 (-105) | ARI: +8.5 (-115)
Total: 43.5 — Over: (-112) | Under: (-108)

The 49ers enter this contest as a heavy favorite on the moneyline and the spread. This Monday night clash also features one of the lower totals on the Week 11 slate at 43.5 points.

49ers vs Cardinals Prediction & Pick

Keep an eye on the health of Murray ahead of this matchup. The 25-year-old continues to nurse a hamstring injury and his status for Monday night remains up in the air. If he is forced to stay on the sideline once again, the 49ers would have a major advantage when it comes to defending the pass.

McCoy did his job on Sunday, but he still averaged only 9.2 yards per completion and now has to face a San Francisco defense that has posted the 10th-best pass defense DVOA rating. Overall, the 49ers have allowed less than 17 points in four of its last six games. They ride their defense to a huge win.

Final Score Prediction: 49ers: 27 | Cardinals: 17

49ers vs Cardinals Betting Trends

- San Francisco is 13-7 against the spread (ATS) in its last 20 games.
- The total has hit the under in 13 of San Francisco's last 17 games.
- Arizona is 11-3 straight up in its last 14 games against San Francisco.
- The total has hit the over in four of Arizona's last five games.

49ers vs Cardinals Best Bet

This is a revenge spot for the 49ers. The Cardinals got the best of them in both 2021 matchups and a win on Monday would keep San Francisco in the race for first place. Look for quarterback Jimmy Garoppolo to lean on tight end George Kittle and wide receiver Deebo Samuel to run up the score.

It's worth pointing out that the 49ers are 5-0 against the spread (ATS) in their last five games against an NFC West opponent, while the Cardinals are 1-6 ATS in their last seven games within the division. I trust San Francisco to find a way to separate in the second half just as it did against LA in primetime.

Bet: San Francisco 49ers -8.5 (-105)

Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.