Week 16 NFL Odds: Predictions, Spreads, Moneylines, and Totals for Every Monday Game

This weekend, 16 NFL games span four days, and a lot of playoff positioning is up for grabs.

Monday's Christmas Day three-game slate features two double-digit spreads but also a game-of-the-year candidate (and a possible Super Bowl preview).

Here are the NFL betting odds for each game in Week 16 on Monday. All game predictions via numberFire.

Raiders at Chiefs Week 16 Odds

• Las Vegas Raiders Moneyline: +385
• Kansas City Chiefs Moneyline: -500
• Spread: Chiefs (-10)
• Total: 40.5
• numberFire Prediction: Chiefs (70.0%)

An AFC West matchup kicks off the Christmas Day NFL festivities at 1:00 pm Eastern. The Raiders are coming off of a dominant 63-21 win over the Chargers on Thursday, so they'll have the rest advantage in this matchup -- but the spread suggests that won't matter much.

The Chiefs won the first matchup in this series by a score of 31-17, though they needed a 14-point comeback to do so after getting off to a slow start.

A Week 15 win over New England now has the Chiefs at 9-5 for the year with great odds to clinch the AFC West.

Key injuries to monitor in this matchup include Josh Jacobs for the Raiders and Jerick McKinnon and Kadarius Toney for the Chiefs.

Giants at Eagles Week 16 Odds

• New York Giants Moneyline: +610
• Philadelphia Eagles Moneyline: -900
• Spread: Eagles (-13.5)
• Total: 43
• numberFire Prediction: Eagles (83.5%)

We've got an NFC East matchup on Christmas Day at 4:30 pm Eastern.

The 5-9 Giants hold a league-worst -149 point differential, a mark that suggest they should have just 2.8 wins based on historical distributions.

The Eagles are in the thick of the NFC East race, and every game will matter here on out with regards to seeding at the top of the conference.

The spread has moved noticeably toward the Eagles throughout the week even after their Monday Night Football loss to the Seahawks, their third straight defeat.

Ravens at 49ers Week 16 Odds

• Baltimore Ravens Moneyline: +190
• San Francisco 49ers Moneyline: -230
• Spread: 49ers (-5.5)
• Total: 46.5
• numberFire Prediction: 49ers (65.9%)

The Christmas Day slate closes out with the two teams holding the 1 seed in their respective conferences.

The Ravens have a great 6-1 road record and are on a four-game winning streak. Lamar Jackson has led the team in rushing in two straight games (70 and 97 yards).

Wide receiver Zay Flowers (foot) isn't 100% entering this game, so we'll need to track updates surrounding his health.

The 49ers remain dominant and have a league-best +191 point differential, which is tied to a six-game winning streak. They've played in only three one-score games this season, tied for the fewest in the NFL.

Looking for the latest NFL odds? Head over to FanDuel Sportsbook and check out all of the NFL betting options.

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The above author is a FanDuel employee and is not eligible to compete in public daily fantasy contests or place sports betting wagers on FanDuel. The advice provided by the author does not necessarily represent the views of FanDuel. Taking the author's advice will not guarantee a successful outcome. You should use your own judgment when participating in daily fantasy contests or placing sports wagers.