Vanderbilt vs Tennessee College Basketball Prediction, Odds, Picks, Best Bets for Feb. 21

The Tennessee Volunteers (19-7, 9-4 SEC) will look to extend a three-game winning streak when they visit the Vanderbilt Commodores (21-5, 8-5 SEC) on February 21, 2026 at Memorial Gymnasium.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Vanderbilt vs. Tennessee Game Info and Odds

• Game day: Saturday, February 21, 2026
• Game time: 2 p.m. ET
• TV channel: ESPN
• Location: Nashville, Tennessee
• Arena: Memorial Gymnasium

Before you wager on Saturday's Vanderbilt-Tennessee spread (Vanderbilt -3.5) or total (149.5 points), take a look at the betting insights and trends below.

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Vanderbilt vs. Tennessee: ATS Betting Stats and Trends

• Vanderbilt has compiled a 14-12-0 record against the spread this season.
• Tennessee is 12-14-0 ATS this season.
• As a 3.5-point underdog or more in 2025-26, Tennessee is 2-1 against the spread compared to the 13-10 ATS record Vanderbilt racks up as a 3.5-point favorite.
• Against the spread, the Commodores have played worse at home, covering seven times in 14 home games, and five times in nine road games.
• This year, the Volunteers are 8-7-0 at home against the spread (.533 winning percentage). Away, they are 2-5-0 ATS (.286).
• Vanderbilt has beaten the spread six times in 13 conference games.
• Tennessee is 6-7-0 against the spread in SEC play this season.

Vanderbilt vs. Tennessee: Moneyline Betting Stats

• Vanderbilt has been chosen as the moneyline favorite in 19 games this year and has walked away with the win 16 times (84.2%) in those games.
• This season, the Commodores have been victorious 15 times in 17 chances when named as a favorite of at least -184 or better on the moneyline.
• Tennessee has a 2-3 record in games it was listed as the moneyline underdog (winning 40% of those games).
• The Volunteers have played as a moneyline underdog of +152 or longer in only one game this season, which they lost.
• The moneyline set for this matchup implies Vanderbilt has a 64.8% chance of coming away with a victory in the contest.

Vanderbilt vs. Tennessee Head-to-Head Comparison

• Vanderbilt's +369 scoring differential (outscoring opponents by 14.2 points per game) is a result of scoring 88.1 points per game (12th in college basketball) while giving up 73.9 per contest (190th in college basketball).
• Tyler's 18.6 points per game lead Vanderbilt and are 70th in the nation.
• Tennessee outscores opponents by 12.1 points per game (posting 81.3 points per game, 71st in college basketball, and giving up 69.2 per contest, 66th in college basketball) and has a +317 scoring differential.
• Nate Ament is 85th in the country with a team-leading 18.2 points per game.
• The Commodores prevail in the rebound battle by an average of 2.5 boards. They are pulling down 33.1 rebounds per game (124th in college basketball) compared to their opponents' 30.6 per contest.
• Devin's 6.9 rebounds per game lead the Commodores and rank 172nd in college basketball play.
• The Volunteers rank third in the nation at 40.2 rebounds per game. That's 14.5 more than the 25.7 their opponents average.
• Ament averages 6.4 rebounds per game (232nd in college basketball) to lead the Volunteers.
• Vanderbilt's 109.3 points per 100 possessions on offense rank 11th in college basketball, and the 91.7 points it allows per 100 possessions rank 100th in college basketball.
• The Volunteers' 102.1 points per 100 possessions on offense rank 80th in college basketball, and the 86.8 points they allow per 100 possessions rank 31st in college basketball.

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