UConn vs Villanova College Basketball Prediction, Odds, Picks, Best Bets for Feb. 21

The Villanova Wildcats (21-5, 12-3 Big East) aim to build on a four-game home winning streak when they host the UConn Huskies (24-3, 14-2 Big East) on February 21, 2026.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

UConn vs. Villanova Game Info and Odds

• Game day: Saturday, February 21, 2026
• Game time: 5:30 p.m. ET
• TV channel: TNT
• Location: Philadelphia, Pennsylvania
• Arena: Xfinity Mobile Arena

Take a look at the betting insights and trends below before making a bet on Saturday's UConn-Villanova spread (UConn -2.5) or total (140.5 points).

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UConn vs. Villanova: ATS Betting Stats and Trends

• UConn has compiled an 8-19-0 ATS record so far this year.
• Villanova has won 17 games against the spread this year, while failing to cover nine times.
• Villanova covers the spread when it is a 2.5-point underdog or more 60% of the time. That's more often than UConn covers as a favorite of 2.5 or more (30.8%).
• The Huskies have covered the spread in a lower percentage of their home games than road games. They have covered three times in 15 games at home, and they've covered four times in nine games on the road.
• The Wildcats' winning percentage against the spread at home is .538 (7-6-0). On the road, it is .700 (7-3-0).
• UConn is 5-11-0 against the spread in conference games this season.
• Villanova is 9-6-0 against the spread in Big East play this year.

UConn vs. Villanova: Moneyline Betting Stats

• UConn has been chosen as the moneyline favorite in 22 games this year and has walked away with the win 19 times (86.4%) in those games.
• The Huskies have a mark of 18-2 in contests where bookmakers favor them by -154 or better on the moneyline.
• Villanova has won 42.9% of the games this season it was the underdog on the moneyline (3-4).
• When they have played as a moneyline underdog with odds of +128 or longer, the Wildcats have a 1-3 record (winning only 25% of their games).
• The moneyline set for this matchup implies UConn has a 60.6% chance of coming away with a victory in the contest.

UConn vs. Villanova Head-to-Head Comparison

• With 77.0 points scored per game and 68.0 points allowed last year, UConn was 90th in the nation offensively and 56th defensively.
• UConn was 111th in college basketball in rebounds per game (33.1) and second-best in rebounds allowed (25.9) last year.
• At 17.3 assists per game, UConn was eighth-best in the country last year.
• UConn was 71st in the country in turnovers per game (10.0) and 317th in turnovers forced (9.8) last year.
• With 74.0 points per game on offense, Villanova was 167th in the country last year. Defensively, it ceded 68.2 points per contest, which ranked 60th in college basketball.
• Villanova averaged 30.9 boards per game last year (239th-ranked in college basketball), and it gave up just 27.7 rebounds per game (17th-best).
• Villanova put up 12.4 assists per game, which ranked them 268th in the nation.
• Villanova ranked top-25 last year in turnovers, 12th-best in college basketball with 9.1 turnovers per game. Meanwhile, it ranked 331st with 9.6 forced turnovers per contest.

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