Thunder vs. Cavaliers Prediction, Odds, Picks, Best Bets for Feb. 22

Thunder vs. Cavaliers Game Info

• Date: Sunday, February 22, 2026
• Time: 1 p.m. ET
• Venue: Paycom Center -- Oklahoma City, Oklahoma
• Coverage: ABC

The Cleveland Cavaliers (36-21) are 3.5-point favorites as they attempt to extend a seven-game winning streak when they visit the Oklahoma City Thunder (43-14) on Sunday, February 22, 2026 at Paycom Center. The game airs at 1 p.m. ET on ABC. The matchup has a point total of 226.5.

Thunder vs. Cavaliers Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Thunder vs. Cavaliers Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Thunder win (73.1%)

Thunder vs. Cavaliers Betting Trends

• The Cavaliers have compiled a 25-32-0 record against the spread this season.
• In the Thunder's 57 games this year, they have 28 wins against the spread.
• Cavaliers games have gone over the total 27 times this season.
• Thunder games this year have hit the over on 31 of 57 set point totals (54.4%).
• Cleveland has covered the spread in a lower percentage of its home games than road games. It has covered 12 times in 30 games at home, and it has covered 13 times in 27 games when playing on the road.
• When it comes to point totals, the Cavaliers hit the over less often when playing at home, as they've exceeded the total 12 times in 30 opportunities this season (40%). On the road, they have hit the over 15 times in 27 opportunities (55.6%).
• This year, Oklahoma City is 14-16-0 at home against the spread (.467 winning percentage). Away, it is 14-12-1 ATS (.519).
• Thunder games have finished above the over/under less frequently at home (14 times out of 30) than away (17 of 27) this year.

Cavaliers Leaders

• Donovan Mitchell is averaging 28.8 points, 5.9 assists and 4.4 boards.
• James Harden averages 24.7 points, 4.8 boards and 8.2 assists.
• Evan Mobley averages 17.7 points, 8.8 boards and 4 assists.
• Jarrett Allen averages 14.9 points, 8.4 boards and 2 assists, shooting 62.7% from the field (seventh in NBA).
• Jaylon Tyson is averaging 13.6 points, 5.3 rebounds and 2.3 assists. Defensively, he averages 0.8 steals and 0.4 blocked shots.

Thunder Leaders

• Chet Holmgren averages 17.4 points for the Thunder, plus 8.7 rebounds and 1.6 assists.
• Cason Wallace averages 8.1 points, 3.1 boards and 2.3 assists. He is also making 42.1% of his shots from the floor and 34% from 3-point range, with 1.3 triples per game.
• Isaiah Hartenstein averages 10.6 points, 9.6 boards and 3.6 assists. He is making 63.6% of his shots from the floor.
• Isaiah Joe's numbers on the season are 10.5 points, 2.6 boards and 1.4 assists per game. He is sinking 44.2% of his shots from the field and 41.7% from 3-point range, with an average of 2.4 triples.
• The Thunder are getting 10.5 points, 3.5 boards and 1.8 assists per game from Aaron Wiggins.

For more NBA betting insights, check out FanDuel Research's NBA home page.

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