Week 1 NFL Odds: NFL Odds and Lines From FanDuel Sportsbook

The NFL is officially back for Week 1 of the 2022 season. Sports bettors were treated to a phenomenal Thursday Night Football performance from Josh Allen and the Buffalo Bills, covering a 2.5-point spread in emphatic fashion. Now, all eyes turn to a number of exciting matchups for the first football Sunday of the year.

Week 1 shows some the potential for some closely fought games, featuring zero games with double-digit spreads and four games at less than a field goal, according to the latest NFL odds on FanDuel Sportsbook.

NFL Spreads Week 1

The largest spread of the week is seen in two games. The Cincinnati Bengals are 7.5-point favorites over the Pittsburgh Steelers. Additionally, the Indianapolis Colts are 7.5-point favorites against the Houston Texans.

NFL Latest Line Week 1

Week 1 may feature a number of low-scoring matchups, as well. In fact, only two of the games on the Week 1 schedule feature over/under lines of at least 50 points. The highest belongs to the Kansas City Chiefs vs Arizona Cardinals at 53.5 points.

The lowest over/under on Sunday's slate belongs to the San Francisco 49ers and Chicago Bears, at 39.5 points.

NFL Lines Week 1

Odds are provided from FanDuel Sportsbook and updated as of Sunday, Sept. 11 at 11:30 a.m. ET.

1. Buffalo Bills 31, Los Angeles Rams 10

2. New Orleans Saints vs Atlanta Falcons

Betting Preview
Moneyline: NO: (-235) | ATL: (+194)
Spread: NO: -5.5 (-110) | ATL: +5.5 (-110)
Total: 43.5 — Over: (-110) | Under: (-110)

3. San Francisco 49ers vs Chicago Bears

Betting Preview
Moneyline: SF: (-280) | CHI: (+230)
Spread: SF: -6.5 (-110) | CHI: +6.5 (-110)
Total: 39.5 — Over: (-110) | Under: (-110)

4. Pittsburgh Steelers vs Cincinnati Bengals

Betting Preview
Moneyline: PIT: (+265) | CIN: (-330)
Spread: PIT: +7.5 (-118) | CIN: -7.5 (-104)
Total: 44.5 — Over: (-110) | Under: (-110)

5. Philadelphia Eagles vs Detroit Lions

Betting Preview
Moneyline: PHI: (-250) | DET: (+205)
Spread: PHI: -5.5 (-110) | DET: +5.5 (-110)
Total: 48.5 — Over: (-110) | Under: (-110)

6. New England Patriots vs Miami Dolphins

Betting Preview
Moneyline: NE: (+148) | MIA: (-178)
Spread: NE: +3.5 (-128) | MIA: -3.5 (+104)
Total: 46.5 — Over: (-105) | Under: (-115)

7. Baltimore Ravens vs New York Jets

Betting Preview
Moneyline: BAL: (-295) | NYJ: (+240)
Spread: BAL: -6.5 (-112) | NYJ: +6.5 (-108)
Total: 44.5 — Over: (-108) | Under: (-112)

8. Jacksonville Jaguars vs Washington Commanders

Betting Preview
Moneyline: JAX: (+130) | WSH: (-154)
Spread: JAX: +2.5 (-104) | WSH: -2.5 (-118)
Total: 43.5 — Over: (-114) | Under: (-106)

9. Cleveland Browns vs Carolina Panthers

Betting Preview
Moneyline: CLE: (+102) | CAR: (-120)
Spread: CLE: +1.5 (-114) | CAR: -1.5 (-106)
Total: 41.5 — Over: (-115) | Under: (-105)

10. Indianapolis Colts vs Houston Texans

Betting Preview
Moneyline: IND: (-335) | HOU: (+270)
Spread: IND: -7.5 (-104) | HOU: +7.5 (-118)
Total: 45.5 — Over: (-115) | Under: (-105)

11. New York Giants vs Tennessee Titans

Betting Preview
Moneyline: NYG: (+198) | TEN: (-240)
Spread: NYG: +5.5 (-114) | TEN: -5.5 (-106)
Total: 43.5 — Over: (-118) | Under: (-104)

12. Green Bay Packers vs Minnesota Vikings

Betting Preview
Moneyline: GB: (+104) | MIN: (-122)
Spread: GB: +1.5 (-110) | MIN: -1.5 (-110)
Total: 46.5 — Over: (-110) | Under: (-110)

13. Kansas City Chiefs vs Arizona Cardinals

Betting Preview
Moneyline: KC: (-260) | ARI: (+215)
Spread: KC: -6.5 (-106) | ARI: +6.5 (-104)
Total: 53.5 — Over: (-112) | Under: (-108)

14. Las Vegas Raiders vs Los Angeles Chargers

Betting Preview
Moneyline: LV: (+152) | LAC: (-180)
Spread: LV: +3.5 (-110) | LAC: -3.5 (-110)
Total: 52.5 — Over: (-106) | Under: (-114)

15. Tampa Bay Buccaneers vs Dallas Cowboys, SNF

Betting Preview
Moneyline: TB: (-142) | DAL: (+120)
Spread: TB: -2.5 (-110) | DAL: +2.5 (-110)
Total: 50.5 — Over: (-110) | Under: (-110)

16. Denver Broncos vs Seattle Seahawks, MNF

Betting Preview
Moneyline: DEN: (-290) | SEA: (+235)
Spread: DEN: -6.5 (-112) | SEA: +6.5 (-108)
Total: 44.5 — Over: (-110) | Under: (-110)

Adam Taylor McKillop is not a FanDuel employee. In addition to providing DFS gameplay advice, Adam Taylor also participates in DFS contests on FanDuel using his personal account, username atmckillop. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.