Oregon vs Colorado Prediction, Odds & Betting Trends for College Football Week 10 Game on FanDuel

Oregon vs Colorado Week 10 Game Info

2022 NCAA College Football Game
No. 8 Oregon Ducks (7-0, 5-0 Pac-12) vs. Colorado Buffaloes (1-7, 1-4 Pac-12)
Date: Saturday, Nov. 5, 2022
Time: 3:30 p.m. ET
Venue: Folsom Field -- Boulder, CO
Coverage: ESPN

Week 10 of the 2022 NCAA college football season includes a best vs worst Pac-12 battle between the No. 8 Oregon Ducks and Colorado Buffaloes. Oregon has won seven straight games including five in a row vs Pac 12 opponents while scoring 42-49 points in each contest. Last week's 42-24 win over Cal was the Ducks fourth straight ATS win.

Meanwhile, Colorado has one win this season. The Buffaloes lost by at least 23 points against their two best Pac 12 opponents UCLA and Oregon State. Last week it was a 42-34 home loss to Arizona State and the Buffs defense allowed more than 550 yards. Colorado scored the last 14 points to get the spread cover, which included an 88 yard punt return TD in the final four minutes.

Oregon vs Colorado Odds & Spread

All NCAAF betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: ORE: (N/A) | COL: (N/A)
Spread: ORE: -31.5 (-110) | COL: +31.5 (-110)
Total: 61.5 — Over: (-110) | Under: (-110)

Oregon enters this contest as a huge road favorite of -31.5 points on the spread. There is no moneyline, and the total is 61.5 - nearly a TD above an average over/under compared to this week's college football projected totals.

Oregon vs Colorado Prediction & Pick

Oregon has averaged 557 yards of total offense over the last four games. During the Ducks 7-game winning streak, QB Bo Nix has a 17:1 TD-INT ratio with a 75% completion rate. Nix has also scored 8 rushing TD's in the last four games. Oregon leads the league in rushing with 235 YPG, and the Ducks have scored a league-high 45 TD's while averaging more than 7.1 yards per play to tie USC on top of the conference.

The Ducks rush defense is No. 1 in the Pac 12 allowing just 105 YPG and Colorado runs the ball for just 113 YPG - second worst in the league. The Buffs pass efficiency offense is worst in the league and completes just 50% passes. Colorado QB J.T. Shrout has completed just 26-of-63 passes the last two games for 428 yard and 3 interceptions. The Ducks defense does allow 280 passing yards per game, so Oregon is far from a dominant defense

Final Score Prediction: Oregon: 43 | Colorado: 16

Oregon vs Colorado Betting Trends

- Oregon is 7-0 straight up (SU) and 6-1 against the spread (ATS) in their last 7 games.
- Oregon is 8-1 SU and 7-2 ATS in their last 9 games vs Colorado.
- The total has hit the Over in 6 of Oregon's last 7 games.
- Colorado is 1-8 SU in their last 9 games and 2-6 ATS in their last 8 contests.
- The total has hit the Over in 6 of Colorado's last 7 games.

Oregon vs Colorado Best Bet

This is a breather for Oregon, and that's the only concern laying huge points on the road. Oregon dominates the stats across the board, and their average margin of victory vs Pac 12 opponents this season is 16 points per game. They will have double that go get the spread cover this week.

But with bigger games to finish the season against Washington, Utah and the rivalry at Oregon State, the Duck's emotional gauge is low for this contest against the bewildered and bad Buffaloes.

Bet: Under 60.5 Points (-110)

Game odds refresh periodically and are subject to change.