Oklahoma State vs Oklahoma Prediction, Odds & Best Bet for Week 12 (Cowboys Put Pair of Oklahoma Streaks in Doubt)

Oklahoma State vs Oklahoma Week 12 Game Info

2022 NCAA College Football Game
No. 22 Oklahoma State Cowboys (7-3, 4-3 Big 12) vs. Oklahoma Sooners (5-5, 2-5 Big 12)
Date: Saturday, Nov. 19, 2022
Time: 7:30 p.m. ET
Venue: Gaylord Family Memorial Stadium — Norman, OK
Coverage: ABC

Week 12 of the 2022 NCAA college football season includes a big rivalry game in the Big 12 between the No. 22 Oklahoma State Cowboys and Oklahoma Sooners. The biggest rivalry games start this weekend anc continue through Thanksgiving weekend and also includes USC at UCLA this Saturday.

Oklahoma State QB Spencer Sanders came off the bench to lead the go-ahead fourth-quarter TD in the Cowboys' 20-14 win over Iowa State last week. Sanders missed most of the game and the previous two contests in defeat with a shoulder issue.

Meanwhile, Oklahoma enters off a pair of 3-point losses to Baylor and West Virginia as a favorite. The Sooners are favored by more than a TD to beat rival Oklahoma State for the ninth time in the last 11 meetings.

Oklahoma State vs Oklahoma Odds & Spread

All NCAAF betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: OKST: (+220) | OKL: (-275)
Spread: OKST: +7.5 (-120) | OKL: -7.5 (-102)
Total: 66.5 — Over: (-110) | Under: (-110)

Oklahoma enters this contest as solid favorite on the spread (-7.5) and moneyline (-275). The takeback on an Oklahoma State outright win is +220. The total has currently sits at 66.5 points - about 10 points higher than an average college football over/under on this week's games.

Oklahoma State vs Oklahoma Prediction & Pick

Oklahoma has won eight of the last 10 games against Oklahoma State, but the Cowboys won last year's Bedlam battle 37-33 when both teams were ranked Top 10 in the CFB Playoff poll. There should be plenty of scoring again with both QB's Spencer Sanders and Dillon Gabriel attacking very deficient defenses.

Oklahoma State's pass defense is the worst in the Big 12 allowing 290 passing yards per game. Oklahoma is dead last in rush defense allowing 200 rushing YPG and allowed nearly 500 rushing yards the last two weeks. The Sooners' defense has consistently allowed at least 200 rushing and nearly 250 passing yards per game. That's a risk for bettors when laying these points.

Final Score Prediction: Oklahoma State: 37 | Oklahoma: 34

Oklahoma State vs Oklahoma Betting Trends

- Oklahoma State is 13-4 straight up (SU) in their last 17 games.
- Oklahoma State is 14-5-1 against the spread (ATS) in their last 20 games.
- The total has gone Under in 11 of Oklahoma State's last 13 road games.
- Oklahoma is 2-5 SU in their last 7 games, but 14-2 in their last 16 home games.
- Oklahoma is 1-6 ATS in their last 7 games.

Oklahoma State vs Oklahoma Best Bet

All NCAAF betting lines, odds and prop bets are available on FanDuel Sportsbook.

Oklahoma is just 5-5 this season in former Clemson defensive coordinator Brent Venables' first year as head coach of the Sooners. Oklahoma has a streak of 23 consecutive years with a winning record. Only Boise State’s 24 is longer. The Sooners’ current bowl streak that began in 1999 also stands at 23 straight — two below Georgia’s 25 in a row.

A loss to Oklahoma State and next week at Texas Tech ends the Sooners' streaks. Don't be surprised if it happens.

Bet: Oklahoma State +7.5 (-115) and Moneyline +220

Game odds refresh periodically and are subject to change.