Ohio State vs Northwestern Prediction, Odds & Betting Trends for College Football Week 10 Game on FanDuel

Ohio State vs Northwestern Week 10 Game Info

2022 NCAA College Football Game
No. 2 Ohio State Buckeyes (8-0, 5-0 Big Ten) vs. Northwestern Wildcats (1-7, 1-4 Big Ten)
Date: Saturday, Nov. 5, 2022
Time: 12:00 p.m. ET
Venue: Ryan Field — Evanston, IL
Coverage: ABC

Week 10 of the 2022 NCAA college football season includes a Big Ten showdown between the No. 2 Ohio State Buckeyes and Northwestern Wildcats. Ohio State mounted a late comeback to beat Penn State by a score of 44-31 on Saturday. Running back TreVeyon Henderson tallied 2 touchdowns.

Meanwhile, Northwestern fell to the Iowa Hawkeyes by a score of 33-13 in Week 9 for its fifth consecutive loss. Quarterback Brendon Sullivan was sacked seven times and also tossed a costly interception. The Wildcats also only logged 60 yards on the ground on 23 carries (2.6-yard average).

Ohio State vs Northwestern Odds & Spread

All NCAAF betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: OSU: (N/A) | NWEST: (N/A)
Spread: OSU: -37.5 (-115) | NWEST: +37.5 (-105)
Total: 61.5 — Over: (-115) | Under: (-105)

Ohio State enters this contest as a heavy favorite on the moneyline and the spread. This Big Ten clash also features a total of 61.5 points, which is above average compared to this week's college football projected totals.

Ohio State vs Northwestern Prediction & Pick

Ohio State passed a big test on Saturday and showed that it knows how to play from behind just as well as it does with a lead. That does not bode well for a Northwestern squad that is giving up 28.8 points per game in conference play. The Buckeyes are going to keep their foot on the gas in this one.

The Wildcats have not taken down the Buckeyes since 2004 and have only kept the final score within one possession once across nine meetings since that victory. Ohio State needs to keep making statements to stay toward the top of the AP Poll, so expect quarterback CJ Stroud to show no mercy.

Final Score Prediction: Ohio State: 48 | Northwestern: 10

Ohio State vs Northwestern Betting Trends

- Ohio State is 9-0 straight up in its last nine games against Northwestern.
- The total has hit the over in each of Ohio State's last six games.
- Northwestern is 3-8 against the spread (ATS) in its last 11 games.
- The total has hit the over in six of Northwestern's last eight games against Ohio State.

Ohio State vs Northwestern Best Bet

As long as this spread stays under 38 points, it is worth backing the Buckeyes on the road. Ohio State is 7-2 against the spread (ATS) in its last nine games against Northwestern. Meanwhile, the Wildcats are 3-8 ATS in their last 11 games overall. This matchup screams blowout on Saturday afternoon.

If you need more reasons to trust Ohio State, the Buckeyes rank first in the entire country in points per game (48.9) and rank eighth in points allowed per game (16.9). Seeing a Wildcats team that averages a dismal 17.0 points per game (No. 120 in FBS) score more than 10 would be shocking.

Bet: Ohio State -37.5 (-115)

Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.