Louisville vs Clemson Prediction, Odds & Betting Trends for College Football Week 11 Game on FanDuel Sportsbook

Louisville vs Clemson Week 11 Game Info

2022 NCAA College Football Game
Louisville Cardinals (6-3, 3-3 ACC) vs. No. 4 Clemson Tigers (8-1, 6-0 ACC)
Date: Saturday, Nov. 12, 2022
Time: 3:30 p.m. ET
Venue: Memorial Stadium — Clemson, SC
Coverage: ESPN

Week 11 of the 2022 NCAA college football season includes an ACC collision between the Louisville Cardinals and No. 4 Clemson Tigers. Louisville is one of the hottest programs in the nation right now, extending its winning streak to four after a 34-10 victory against James Madison over the weekend.

Winning won't be easy for the Cardinals, who have to deal with an angry Tigers team. Clemson suffered its first loss of the year on Saturday, losing 35-14 to Notre Dame on the road. The Tigers' offense looked lethargic, amassing just 281 total yards without scoring a single point until the fourth quarter.

Louisville vs Clemson Odds & Spread

All NCAAF betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: LOU: (+220) | CLEM: (-275)
Spread: LOU: +7 (-110) | CLEM: -7 (-110)
Total: 51.5 — Over: (-110) | Under: (-110)

Clemson enters this contest as a clear home favorite on the spread and moneyline. This 3:30 p.m. ET clash also features a total of 51.5, which is average compared to this week's projected totals.

Louisville vs Clemson Prediction & Pick

Clemson must use this game to get back on track after losing to Notre Dame. Fortunately, the conditions are right for that to happen. Not only are the Tigers 9-0 in their last nine conference matchups, but they've also won 20 straight games at Memorial Stadium.

Meanwhile, Louisville is an unimpressive 3-3 against the ACC this season. Those three losses came against Boston College, Syracuse and Florida State — all teams that Clemson has beaten since the beginning of October.

Aside from a victory over then-No. 10 Wake Forest, the Cardinals haven't exactly been beating notable opponents this fall. Besides, the Tigers also defeated the Demon Deacons and are a solid 3-0 against ranked schools this season.

Things haven't been perfect, but it's tough imagining Clemson losing back-to-back games. Back the Tigers to get back on the right track this weekend.

Final Score Prediction: Clemson: 37 | Louisville: 30

Louisville vs Clemson Betting Trends

- Louisville is 0-7 straight up in its last seven games against Clemson.
- Clemson is 5-2 against the spread (ATS) in its last seven games against Louisville.
- The total has hit the over in four of Louisville's last five games against Clemson.
- The total has hit the over in six of Clemson's last eight games against the Atlantic Division.

Louisville vs Clemson Best Bet

All NCAAF betting lines, odds and prop bets are available on FanDuel Sportsbook.

I expect to see a lot of offensive action when Louisville and Clemson meet this Saturday. Both programs boast top-50 offenses this season while neither defense has been unbeatable in recent weeks. Furthermore, the two sides have averaged a total of 69.6 over the last five meetings, finishing with over 51.5 points in each of those games.

With Louisville looking to continue their winning streak and Clemson wanting revenge for last week's loss, I'm backing the over on the total.

Bet: Over 51.5 Points (-110)

Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.

Game odds refresh periodically and are subject to change.