Indiana vs Ohio State Prediction, Odds & Betting Trends for College Football Week 11 Game on FanDuel Sportsbook

Indiana vs Ohio State Week 11 Game Info

2022 NCAA College Football Game
Indiana Hoosiers (3-6, 1-5 Big Ten) vs. No. 2 Ohio State Buckeyes 9-0, 6-0 Big Ten)
Date: Saturday, Nov. 12, 2022
Time: 12:00 p.m. ET
Venue: Ohio Stadium — Columbus, OH
Coverage: FOX

Week 11 of the 2022 NCAA college football season includes a Big Ten battle in Columbus between the Indiana Hoosiers and No. 2 Ohio State Buckeyes.

Ohio State remains undefeated and No. 2 in the CFB Playoff poll. The Buckeyes struggled last week in the rain and wind in Evanston to beat Northwestern 21-7 as a 38-point favorite. Heisman favorite CJ Stroud was just 10-of-26 passing for 78 yards.

Meanwhile, Indiana was buried at home by Penn State 45-14 and dominated statistically. The Hoosiers played without starting QB Connor Bazelak, and the backup was KO'd during the game forcing third and fourth string quarterback's into action., and they threw three INT's in 17 pass attempts.

Indiana vs Ohio State Odds & Spread

All NCAAF betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: IND: (NA) | OSU: (NA)
Spread: IND: +40.5 (-108) | OSU: -40.5 (-112)
Total: 57.5 — Over: (-110) | Under: (-110)

Ohio State enters this contest as a mammoth home favorite on the spread (-40.5). This Big Ten clash also features a total of 57.5 points, which is slightly about average compared to this week's college football projected totals.

Indiana vs Ohio State Prediction & Pick

Until last week, the Buckeyes had rattled off 7-straight wins by 29 points or more. The spreads have been huge, and this week favorite bettors are salivating again knowing too that Ohio State has crushed Indiana in two recent meetings, 51-10 and last year 56-7 with both on the road.

The Buckeye's offensive profile is elite with balance and power averaging 484 yards per game despite last week's weather induced 283 yards output. This week, the offensive projections are over 550 yards with a dominant edge in the running game. Indiana is last in rushing in the Big Ten averaging just 78 YPG while allowing 157 YPG. The Hoosiers have allowed a league-worst 37 TD's and 32 points per game. Ohio State is also a defensive dominator and among the nation's leaders allowing just 272 yards per game and 15.8 points per game.

Heavy rainfall will hit Columbus Friday before clearing Saturday with 10+ MPH winds. That's not enough to slow the Buckeye's, but the huge spread is the equalizer.

Final Score Prediction: Ohio State: 45 | Indiana: 10

Indiana vs Ohio State Betting Trends

- Indiana is 0-6 straight up (SU) in there last 6 games, and 0-10 vs Ohio State the last 10 meetings.
- Indiana is 0-5 against the spread (ATS) in their last 5 road games.
- Ohio State is 10-0 SU in their last 10 games, and 12-0 SU in their last 12 home games.
- The total has hit the Over in 5 of Ohio State's last 6 games.

Indiana vs Ohio State Best Bet

Indiana QB Connor Bazelak will return to the starting role this week with Dexter Williams II the backup as a duel threat if Bazelak encounters any issues. Ohio State is clearly capable of another blowout win, but the lines are just ridiculously high. Bet on the Buckeye's at your own risk.

Bet: Indiana +40.5 (-108)

Game odds refresh periodically and are subject to change.