Duke vs Louisville Prediction, Odds & Best Bet for February 20 (Can the Blue Devils Stay Undefeated at Home?)

Duke vs Louisville Game Info

• 2022-23 NCAA Basketball Regular Season Game
• Duke (19-8, 10-6 ACC) vs. Louisville (4-23, 2-14 ACC)
• Date: Monday, February 20, 2023
• Time: 7:00 PM ET
• Venue: Cameron Indoor Stadium -- Durham, North Carolina
• Coverage: ESPN

The 2022-23 college basketball season continues on Monday with an exciting matchup between the Louisville Cardinals and Duke Blue Devils. Louisville is coming off a thrilling 83-73 win over Clemson on Saturday. El Ellis balled out with 28 points, while JJ Traynor racked up 16 points & 9 rebounds.

Meanwhile, Duke crushed Syracuse by a score of 77-55 on Saturday to earn its fifth win in its last seven games. Kyle Filipowski posted a double-double (14 points & 12 rebounds) and the Blue Devils shot 50.0% from three-point range (13-of-26). Which ACC team will keep momentum rolling tonight?

Duke vs Louisville Odds & Spread

• All college basketball betting lines, odds and prop bets are from FanDuel Sportsbook.
• Moneyline: DUKE: (-3500) | LOUIS: (+1280)
• Spread: DUKE: -18.5 (-105) | LOUIS: +18.5 (-115)
• Total: 137.5 -- Over: (-110) | Under: (-110)

Duke enters this contest as a heavy home favorite on the moneyline and spread per FanDuel Sportsbook's odds. This 7 p.m. ET clash also features an over/under of 137.5 points, which is about average compared to Monday's projected totals.

Duke vs Louisville Betting Trends

• Duke has covered the spread 10 times in 27 games.
• As a 19.5-point favorite or greater, the Blue Devils have two wins ATS (2-3).
• This season, 10 of Duke's 27 games have hit the over.
• Louisville has 10 wins in 27 games against the spread this year.
• The Cardinals have won once ATS (1-1) as a 19.5-point underdog or more this year.
• Louisville has played 27 games this season, and 13 of them have gone over the total.

Duke Rank	Duke AVG		Louisville AVG	Louisville Rank
176th	71.6	Points Scored	64.5	335th
35th	64	Points Allowed	75.4	326th
16th	36.2	Rebounds	30.1	272nd
12th	11.4	Off. Rebounds	7.6	266th
227th	7	3pt Made	6.6	262nd
73rd	14.7	Assists	9.3	362nd
206th	12.2	Turnovers	14.3	337th

Duke vs Louisville Prediction & Pick

Saturday's win was just Louisville's fourth of the season as it remains last in the ACC standings. The Cardinals have found little success on either side of the court, ranking 328th in offensive efficiency and 339th in defensive efficiency. Seeing them beat Duke tonight would be shocking to say the least.

The Blue Devils have been unstoppable at home this season. They have posted a perfect 13-0 record to go along with a +16.7 average scoring margin at Cameron Indoor Stadium. Duke gives up just 59.9 points per home game as well. It won't be a matter of if they defeat the Cardinals. It'll be by how much.

Louisville has lost 15 of its last 17 games against an ACC opponent, so fade the Cardinals here.

Final Score Prediction: Duke: 74 | Louisville: 58

Duke vs Louisville Best Bet

There's a lot to like about backing the under in this ACC showdown. Duke plays at one of the slowest paces in the country, averaging only 67.9 possessions per game (No. 283 in NCAA). Louisville checks in at 220th in that same category (69.2 possessions). Each side tends to take its time on offense.

Duke owns the 30th-best defensive efficiency mark in home games, too. It should be able to shut down Louisville's offense, while it methodically scores on offense. The total has hit the under in four of the Blue Devils' last five games overall and in five of their last seven games against the Cardinals.

Bet: Under 137.5 Points (-110)

Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.