Cowboys vs 49ers Prediction, Odds & Best Bets for NFC Divisional Round Playoff Game (San Francisco Pulls Away Late)

Cowboys vs 49ers Playoff Game Info

2022 NFL Playoffs — NFC Divisional Round Game
Dallas Cowboys (12-5, 4-4 Away) vs. San Francisco 49ers (13-4, 8-1 Home)
Date: Sunday, Jan. 22, 2023
Time: 6:30 p.m. ET
Venue: Levi's Stadium — Santa Clara, CA
Coverage: FOX

The NFL Playoffs started with a bang as the Wild Card Round featured no shortage of exciting games. Up next is the Divisional Round, which concludes with a clash between the Dallas Cowboys and San Francisco 49ers on Sunday, Jan. 22. These two teams have not faced off since the 2021 postseason.

Dallas enters as a victor in six of its last eight games and opened with a big win over the Tampa Bay Buccaneers thanks to quarterback Dak Prescott's stellar performance. Meanwhile, San Francisco has won 11 straight games and relied on its defense to frustrate the Seattle Seahawks in a Wild Card win.

Will the 49ers make it to the NFC Championship for the third time in the last four years? Or will the Cowboys advance past the Divisional Round for the first time since 1995?

Cowboys vs 49ers Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: DAL: (+156) | SF: (-186)
Spread: DAL: +4 (-114) | SF: -4 (-106)
Total: 46 — Over: (-110) | Under: (-110)
Odds to Win Super Bowl: DAL: +850 | SF: +450

The 49ers enter this contest as small home favorites on both the moneyline and spread on FanDuel Sportsbook. This Sunday evening clash features an over/under mark of 46 points, the lowest total of the Divisional Round matchups.

Cowboys vs 49ers Prediction & Pick

The Cowboys proved the doubters wrong in their Monday night win. Aside from kicker Brett Maher's four missed extra points, the team played nearly perfect. Prescott accounted for 5 total touchdowns and the Dallas defense held its opponent to under 20 points for an impressive 10th time this season.

As good as the Cowboys played, the 49ers were even better. San Francisco dropped 41 points on Seattle and forced 2 crucial turnovers. It was more of the same from a dominating team. The 49ers rank fifth in the NFL in points scored per game (27.3) and tied for second in total turnovers (30).

Home-field advantage is going to be the deciding factor here. San Francisco is 8-1 at Levi's Stadium this season and has posted an average scoring margin of +13.7 at home. Dallas took down Tampa Bay on the road, but the Cowboys rank outside the top 12 in yards allowed per away game this year.

Final Score Prediction: Cowboys: 20 | 49ers: 27

Cowboys vs 49ers Betting Trends

- Dallas is 6-2 straight up in its last eight games against San Frncisco.
- The total has hit the under in four of Dallas' last five away games.
- San Francisco is 6-0 against the spread (ATS) in its last six home games.
- The total has hit the over in six of San Francisco's last seven games.

Cowboys vs 49ers Best Bet

It's hard to understate just how well the 49ers have been playing during a stretch that has almost reached three months. The 49ers are 8-1 against the spread (ATS) in their last nine games and 6-0 ATS in their last six home games. They have won by more than 4 points in 10 of their last 11 games.

Dallas is a dismal 2-9 ATS in their last 11 games in January and have experienced firsthand what it is like to play San Francisco in the postseason. The 49ers took down the Cowboys by a score of 23-17 at AT&T Stadium in the Wild Card Round last postseason. I'll back the home team to pull away here.

Bet: San Francisco 49ers -4 (-110)

Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.