Colorado vs USC Prediction, Odds & Betting Trends for College Football Week 11 Game on FanDuel Sportsbook

Colorado vs USC Week 11 Game Info

2022 NCAA College Football Game
Colorado Buffaloes (1-8, 1-5 Pac 12) vs. No. 8 USC Trojans (8-1, 6-1 Pac 12)
Date: Friday, Nov. 11, 2022
Time: 9:30 p.m. ET
Venue: LA Memorial Coliseum — Los Angeles, CA
Coverage: FS1

Week 11 of the 2022 NCAA college football season includes a best vs worst Friday night feature in the Pac 12 between the No. 8 USC Trojans and Colorado Buffaloes. Southern Cal is 6-1 in Pac 12 play and the Trojans have consistently scored at least 40 points. Colorado can't get out of their own way. The Buffaloes were stampeded again last week 49-10 by Oregon, who is unbeaten in Pac 12 play.

Colorado has allowed at least 40 points in 5-of-6 Pac 12 games.

Colorado vs USC Odds & Spread

All NCAAF betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: COL: (+2200) | USC: (NA)
Spread: COL: +34.5 (-112) | USC: -34.5 (-108)
Total: 62.5 — Over: (-110) | Under: (-110)

Southern Cal enters this contest as a monster favorite (-34.5) on the spread and no moneyline available. However, you can bet Colorado to win the game at +2200 on the moneyline. The total is 62.5, which is about a touchdown higher than average compared to this week's college football projected totals.

Colorado vs USC Prediction & Pick

USC Trojans QB Caleb Williams passed for 360 yards and 4 TD's in last week's 42-35 win over Cal. The Trojans are averaging 41 points per game while the Buffaloes are among the very worst in college football averaging just 15.5 points per game. The stats all point USC's way of course, but the Trojans do have their big crosstown rivalry game next week against UCLA.

Colorado quarterbacks are completing just 50% of their passes for 189 YPG at 5.9 yards per pass and 8 touchdowns. The Buffs have reached the red zone a conference low 24 times and converted just 17 scores (11 TDs). Trojans QB Caleb Williams has passed for 2742 yards - more than 300 per game and a 28:1 TD-to-INT ratio. Sothern Can also runs for 183 YPG, and the Trojans can run up the score if they wish.

Final Score Prediction: USC: 55 | Colorado: 16

Colorado vs USC Betting Trends

- Colorado is 1-9 straight up (SU) in their last 10 games.
- Colorado is 2-7 against the spread (ATS) in their last 9 games.
- Colorado is 0-9 SU in their last 9 road games.
- USC is 8-1 SU in their last 9 games, and 5-0 SU in their last 5 home games.
- The total has gone Over in 4 of USC's last 5 games.

Colorado vs USC Best Bet

Colorado ranks last in pass efficiency defense, rush defense (232/game) and have a -10 turnover margin. USC is +16 in TO margin and this is as lopsided as CU's game vs Oregon last week. USC's motivation and interest in keeping their ranking high will determine the final score, along with weather coach Lincoln Riley pulls more starters in the fourth quarter.

Bet: USC -34.5 (-108)