Bills vs Rams Prediction, Odds & Betting Trends for NFL Week 1 Game on FanDuel Sportsbook (Sept. 8)

Bills vs Rams Week 1 Game Info

2022 NFL Regular Season — Week 1 Game
Buffalo Bills (0-0, 0-0 Away) vs. Los Angeles Rams (0-0, 0-0 Home)
Date: Thursday, September 8, 2022
Time: 8:20 p.m. ET
Venue: SoFi Stadium — Inglewood, CA
Coverage: NBC

The Buffalo Bills and Los Angeles Rams meet head-to-head on Thursday Night Football to kick off the 2022 NFL regular season. The Bills enter the fall as the favorite to capture the Lombardi Trophy and have an MVP candidate in quarterback Josh Allen leading a powerful offensive attack.

Meanwhile, the Rams will be looking to keep their momentum going after winning the Super Bowl back in February. Quarterback Matthew Stafford has a new weapon to target in wide receiver Allen Robinson and Aaron Donald has a new veteran to bond with on defense in linebacker Bobby Wagner.

Bills vs Rams Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: BUF: (-134) | LAR: (+114)
Spread: BUF: -2.5 (-110) | LAR: +2.5 (-110)
Total: 51.5 — Over: (-110) | Under: (-110)
Odds to Win Super Bowl 57: BUF: (+600) | LAR: (+1100)

Updated (Thursday, Sept. 8, 12:45 p.m. EST): Updated odds were provided from FanDuel Sportsbook. Since these odds movement, not much has changed on the line save for the point total dropping from 52.5 to 51.5 points.

The Bills enter this contest as a small favorite on the moneyline and the spread. This Thursday night football clash also features the second-highest total of the NFL Week 1 slate.

Bills vs Rams Prediction & Pick

This is a matchup between two of the best offenses in the NFL. In fact, both the Bills and the Rams ranked among the top 10 teams in yards, touchdowns and points per game in 2021. It's safe to say there's going to be some offensive fireworks, so this one will come down to key defensive stops.

Buffalo finished with the No. 1 total DVOA rating last year and then signed veteran Von Miller in the offseason. As if that move wasn't enough to trust their defense, the Bills also used a first-round pick on cornerback Kaiir Elam. The Florida product has the skills to make a difference as soon as Week 1.

Final Score Prediction: Bills: 31 | Rams: 24

Bills vs Rams Betting Trends

- Buffalo is 4-1 against the spread (ATS) in its last five games against the Rams.
- The total has hit the over in four of Buffalo's last five away games.
- The Rams are 4-1 straight up in their last five games played on a Thursday.
- The total has hit the over in eight of the Rams' last nine games against Buffalo.

Bills vs Rams Best Bet

All NFL betting lines, odds and prop bets are available on FanDuel Sportsbook.

It's simple to think that NFL offenses are going to start out slow at the beginning of the season, but that hasn't been the case as of late. Three of the last five NFL kickoff games have seen more than 53 total points scored. Betting the over has a ton of value, but there's one other bet that's even better.

Nine of the last 13 NFL kickoff games have been decided by one possession. When the bright lights are on, teams play their best football and live up to their competition. Seeing this game end in a blowout either way would be surprising, so take the Bills to win in a close one for a bigger payout.

Bet: Buffalo Bills Win by 1-13 Points (+145)

Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.